FlyBase Allele Report: Dmel\dos::Hsap\GAB1[hs.2sev.GFP]

General Information

Symbol

Dmel\dos::Hsap\GAB1^hs.2sev.GFP

Species

D. melanogaster

Name

FlyBase ID

FBal0104657

Feature type

allele

Associated gene

dos::Hsap\GAB1

Associated Insertion(s)

Carried in Construct

P{hs-PH.GAB1-dos-GFP}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Bausenwein et al., 2000)

Progenitor genotype

dos^hs.2sev.GFP

(Bausenwein et al., 2000)

Carried in construct

P{hs-PH.GAB1-dos-GFP}

Cytology

Description

The dos PH domain has been replaced by the dos::Hsap\GAB1 PH domain.

(Bausenwein et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

dos::Hsap\GAB1

Tagged with

GFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

dos::Hsap\GAB1^hs.2sev.GFP is an enhancer of photoreceptor cell R7 phenotype of dos^R31, sev^S11.Tag:MYC

(Bausenwein et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of dos::Hsap\GAB1^{hs.T:Avic\GFP} to dos^R31/sev^{S11.T:Hsap\MYC} flies restores the multiple R7 phenotype suppressed in sev^{S11.T:Hsap\MYC} flies when dos^R31 is added. The addition of dos::Hsap\GAB1^{hs.T:Avic\GFP} to dos^R31 or dos^P115 homozygotes or dos^P115/dos^R31 flies leads to the recovery of fully viable flies.

(Bausenwein et al., 2000)

Xenogenetic Interactions

Statement

Reference

The addition of dos::Hsap\GAB1^{hs.T:Avic\GFP} to dos^R31/sev^{S11.T:Hsap\MYC} flies restores the multiple R7 phenotype suppressed in sev^{S11.T:Hsap\MYC} flies when dos^R31 is added.

The addition of dos::Hsap\GAB1^{hs.T:Avic\GFP} to dos^R31 or dos^P115 homozygotes or dos^P115/dos^R31 flies leads to the recovery of fully viable flies.

(Bausenwein et al., 2000)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dos::Hsap\GAB1^hs.2sev.GFP

dos::Hsap\GAB1^hs.GFP

dos::Hsap\GAB1^{hs.T:Avic\GFP}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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