FB2026_02 , released June 18, 2026
Allele: Dmel\Oct-TyrRhono
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General Information
Symbol
Dmel\Oct-TyrRhono
Species
D. melanogaster
Name
honoka
FlyBase ID
FBal0104701
Feature type
allele
Associated gene
Dmel\Oct-TyrR
Associated Insertion(s)
P{lwB}Oct-TyrRhono
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kutsukake and Hirsh, 2001.7.19, Kutsukake et al., 2000)
Progenitor genotype
Associated Insertion(s)
P{lwB}Oct-TyrRhono
Cytology
Description

P{lwB} is inserted about 100bp upstream of the first non-coding, previously undescribed exon of the TyrR gene.

(Kutsukake and Hirsh, 2001.7.19)

Stated to be a P{lwB} insertion about 100bp upstream of the TyrR gene. See FBrf0139901 and FBrf0126774 for further discussion of the molecular nature of the TyrRhono lesion.

(Kutsukake et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lwB}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Oct-TyrRhono larvae have a significant increase in the distance they crawl, relative to controls.

      (Selcho et al., 2012)

      The enhancement of EJPs by octopamine is similar to that in wild type larvae. The inihibitory effect of EJPs by tyramine is completely eliminated.

      (Nagaya et al., 2002)

      The avoidance behaviour of TyrRhono flies in response to the repellents ethyl acetate, benzaldehyde and 4-methylcycrohexanol is impaired compared to wild-type flies. Locomotor activity of both males and females is normal and slightly increased compared to wild-type flies. The excitatory junctional potential of TyrRhono larval body wall muscles is not inhibited by 10-6M tyramine, in contrast to wild type.

      (Kutsukake et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Oct-TyrRneo30

      (Kutsukake et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: an olfactory behavioural mutant which is defective in responses to some repellents in a T-maze assay.

      (Kutsukake et al., 2000)
      Comments
      Comments

      Reversion analysis shows that the P{lwB} insertion is responsible for the olfactory mutant phenotype.

      (Kutsukake et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Oct-TyrRhono
      (Ma and Freeman, 2020, Ma et al., 2016)
      TyrRhono
      hono
      (Blenau and Baumann, 2001, Kutsukake et al., 2000)
      honohono
      honoka
      (Selcho et al., 2012)
      oct-tyrRhono
      (Schützler et al., 2019)
      Name Synonyms
      honoka
      (Damrau et al., 2017, Roeder et al., 2003, Nagaya et al., 2002, Vanden Broeck, 2001)
      Secondary FlyBase IDs
        References (11)