FlyBase Allele Report: Dmel\trbl[UAS.cMa]

General Information

Symbol

Dmel\trbl^UAS.cMa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Mata

FlyBase ID

FBal0117318

Feature type

allele

Associated gene

Dmel\trbl

Associated Insertion(s)

Carried in Construct

P{UAS-trbl.M}

Also Known As

UAS-tribbles

Key Links

Transgenic product class

wild_type

(Mata et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Mata et al., 2000)

Mutagen

in vitro construct

(Mata et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-trbl.M}

Cytology

Description

UAS regulatory sequences drive expression of trbl.

(Mata et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

trbl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by BacA\p35^UAS.cHa, Bub3^GD9924

(Muzzopappa et al., 2017)

modeled by Ras85D^V12.UAS, dlg1^GD4689

(Muzzopappa et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number, with Scer\GAL4^en-e16E

(Mata et al., 2000)

decreased occurrence of cell division | third instar larval stage, with Scer\GAL4^en-e16E

(Mata et al., 2000)

increased cell size, with Scer\GAL4^en-e16E

(Mata et al., 2000)

Phenotype Manifest In

border follicle cell, with Scer\GAL4^slbo.2.6

(Rorth et al., 2000)

wing blade posterior compartment, with Scer\GAL4^en-e16E

(Mata et al., 2000)

wing disc posterior compartment, with Scer\GAL4^en-e16E

(Mata et al., 2000)

Detailed Description

Statement

Reference

Expression of trbl^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E results in wings with a posterior compartment of close to normal size and pattern, but made up of fewer, larger cells than normal. The posterior cells of wing discs expressing trbl^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E are also fewer and larger than control cells. Almost all of the posterior cells are in G2/M. Very few mitotic cells are seen in the imaginal discs, suggesting that the G2 phase of the posterior wing imaginal disc cells is slowed substantially by expression of trbl^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E.

(Mata et al., 2000)

Expression of trbl^Scer\UAS.cMa under the control of Scer\GAL4^slbo.2.6 completely prevents border cell migration. There is no effect on centripetal cell migration.

(Rorth et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, trbl^UAS.cMa has increased cell size phenotype, suppressible by Scer\GAL4^en-e16E/stg^UAS.cNa

(Mata et al., 2000)

Scer\GAL4^en-e16E, trbl^UAS.cMa has decreased cell number phenotype, suppressible by Scer\GAL4^en-e16E/stg^UAS.cNa

(Mata et al., 2000)

Suppressor of

Statement

Reference

trbl^UAS.cMa, Scer\GAL4^ap-md544 is a suppressor | partially of neoplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689

(Muzzopappa et al., 2017)

trbl^UAS.cMa, Scer\GAL4^ap-md544 is a suppressor of neoplasia | larval stage phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, trbl^UAS.cMa has wing disc | posterior phenotype, suppressible by Scer\GAL4^en-e16E/stg^UAS.cNa

(Mata et al., 2000)

Scer\GAL4^en-e16E, trbl^UAS.cMa has wing | posterior phenotype, suppressible by Scer\GAL4^en-e16E/stg^UAS.cNa

(Mata et al., 2000)

Suppressor of

Statement

Reference

trbl^UAS.cMa, Scer\GAL4^ap-md544 is a suppressor | partially of wing disc phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544, dlg1^GD4689

(Muzzopappa et al., 2017)

trbl^UAS.cMa, Scer\GAL4^ap-md544 is a suppressor of wing disc phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Muzzopappa et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^sd-SG29.1/trbl^UAS.cMa is a non-suppressor of dorsal-ventral compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^sd-SG29.1, mir-ban^C.UAS.EGFP

(Becam et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of trbl^Scer\UAS.cMa is unable to suppress the dorsal-ventral boundary defects seen when ban^{C.Scer\UAS.T:Avic\GFP-EGFP} is expressed under the control of Scer\GAL4^sd-SG29.1.

(Becam et al., 2011)

Coexpression of stg^Scer\UAS.cNa suppresses the effects of overexpression of trbl^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E in imaginal disc cells.

(Mata et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

trbl^Scer\UAS.cMa

trbl^UAS.cMa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Mata

(Mata et al., 2000)

Secondary FlyBase IDs

References (6)

Report Sections

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