FB2026_02 , released June 18, 2026
Allele: Dmel\sisA2
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General Information
Symbol
Dmel\sisA2
Species
D. melanogaster
Name
FlyBase ID
FBal0117360
Feature type
allele
Associated gene
Dmel\sisA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Walker et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q161term.

(Walker et al., 2000)

Nucleotide substitution: C?T.

(Walker et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,321,810..11,321,810 [-]
Nucleotide change:

C11321810T

Reported nucleotide change:

C?T

Amino acid change:

Q161term | sisA-PA

Reported amino acid change:

Q161term

(Walker et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant clones in gynandromorphs are recovered in every adult structure with similar frequency. The average size of the null mutant patches is quite large. Many mosaics have more than half male tissue and some are almost entirely male.

      (Walker et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      sisA2/sisA1 has lethal | female phenotype, suppressible by SxlM4

      (Walker et al., 2000)
      NOT suppressed by
      Statement
      Reference

      sisA2 has lethal | recessive | female phenotype, non-suppressible by SxlM4

      (Walker et al., 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sisA1

      (Walker et al., 2000)
      Rescued by

      sisA2 is rescued by sisA+t6.4

      (Walker et al., 2000)
      Not rescued by

      sisA2 is not rescued by sisAA10m2

      (Walker et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sisA2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)