FlyBase Allele Report: Dmel\sbb[A.GMR.Tag:MYC]

General Information

Symbol

Dmel\sbb^{A.GMR.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0117378

Feature type

allele

Associated gene

Dmel\sbb

Associated Insertion(s)

Carried in Construct

P{GMR-sbb.A.myc}

Key Links

Transgenic product class

wild_type

(Senti et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Senti et al., 2000)

Mutagen

in vitro construct

(Senti et al., 2000)

Progenitor genotype

Carried in construct

P{GMR-sbb.A.myc}

Cytology

Description

GMR regulatory sequences drive expression of the sbb A isoform, tagged at the 5' end with 8 tandem copies of Tag:MYC.

(Senti et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

sbb

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

photoreceptor cell R1 & axon | somatic clone, with sbb¹

(Senti et al., 2000)

photoreceptor cell R1 & axon | somatic clone, with sbb²

(Senti et al., 2000)

photoreceptor cell R2 & axon | somatic clone, with sbb¹

(Senti et al., 2000)

photoreceptor cell R2 & axon | somatic clone, with sbb²

(Senti et al., 2000)

photoreceptor cell R3 & axon | somatic clone, with sbb¹

(Senti et al., 2000)

photoreceptor cell R3 & axon | somatic clone, with sbb²

(Senti et al., 2000)

photoreceptor cell R4 & axon | somatic clone, with sbb¹

(Senti et al., 2000)

photoreceptor cell R4 & axon | somatic clone, with sbb²

(Senti et al., 2000)

photoreceptor cell R5 & axon | somatic clone, with sbb¹

(Senti et al., 2000)

photoreceptor cell R5 & axon | somatic clone, with sbb²

(Senti et al., 2000)

photoreceptor cell R6 & axon | somatic clone, with sbb¹

(Senti et al., 2000)

photoreceptor cell R6 & axon | somatic clone, with sbb²

(Senti et al., 2000)

Detailed Description

Statement

Reference

R7 and R8 photoreceptor cell axons extend normally through the lamina to terminate in the medulla in animals expressing sbb^{A.GMR.T:Hsap\MYC}.

(Senti et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

sbb^{A.GMR.Tag:MYC} partially rescues sbb¹

(Senti et al., 2000)

sbb^{A.GMR.Tag:MYC} partially rescues sbb²

(Senti et al., 2000)

Comments

The photoreceptor R1-R6 cell targeting defects of sbb¹ or sbb² mosaics (in which almost all of the eye is homozygous for the sbb mutation while other tissues are heterozygous) are partially rescued by sbb^{A.GMR.T:Hsap\MYC}; most R1-R6 axons correctly target the lamina, although a small number of R1-R6 axons in each hemisphere, predominantly those in the posterior regions of the eye, still project through the lamina to terminate in the medulla.

(Senti et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sbb^{A.GMR.T:Hsap\MYC}

sbb^{A.GMR.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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