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General Information
Symbol
Dmel\sbb1
Species
D. melanogaster
Name
FlyBase ID
FBal0117382
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
bks1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

photoreceptor cell & axon | somatic clone (with sbb2)

photoreceptor cell R1 & axon | somatic clone

photoreceptor cell R1 & axon | somatic clone, with sbbA.GMR.Tag:MYC

photoreceptor cell R1 & axon | somatic clone (with sbb04440)

photoreceptor cell R1 & axon | somatic clone (with sbbk00702)

photoreceptor cell R2 & axon | somatic clone

photoreceptor cell R2 & axon | somatic clone, with sbbA.GMR.Tag:MYC

photoreceptor cell R2 & axon | somatic clone (with sbb04440)

photoreceptor cell R2 & axon | somatic clone (with sbbk00702)

photoreceptor cell R3 & axon | somatic clone

photoreceptor cell R3 & axon | somatic clone, with sbbA.GMR.Tag:MYC

photoreceptor cell R3 & axon | somatic clone (with sbb04440)

photoreceptor cell R3 & axon | somatic clone (with sbbk00702)

photoreceptor cell R4 & axon | somatic clone

photoreceptor cell R4 & axon | somatic clone, with sbbA.GMR.Tag:MYC

photoreceptor cell R4 & axon | somatic clone (with sbb04440)

photoreceptor cell R4 & axon | somatic clone (with sbbk00702)

photoreceptor cell R5 & axon | somatic clone

photoreceptor cell R5 & axon | somatic clone, with sbbA.GMR.Tag:MYC

photoreceptor cell R5 & axon | somatic clone (with sbb04440)

photoreceptor cell R5 & axon | somatic clone (with sbbk00702)

photoreceptor cell R6 & axon | somatic clone

photoreceptor cell R6 & axon | somatic clone, with sbbA.GMR.Tag:MYC

photoreceptor cell R6 & axon | somatic clone (with sbb04440)

photoreceptor cell R6 & axon | somatic clone (with sbbk00702)

Detailed Description
Statement
Reference

Embryos derived from homozygous germline clones show segmentation defects, with loss of denticle belts.

Third instar larvae transheterozygous for sbb1/sbb324 display a significant increase in turning rate during crawling, as compared to controls.

Mosaics in which almost all of the eye is homozygous for sbb1 while other tissues are heterozygous (clones generated using the "eyFLP" system) show striking defects in photoreceptor axon projections; photoreceptor axons project normally through the optic stalk to the brain, but fail to segregate into their distinct target layers. Only a vestigial lamina plexus is formed, while thick bundles of photoreceptor axons project through to the medulla. R1-R6 photoreceptor axons overshoot their targets in sbb1/sbb04440 or sbb1/sbbk00702 transheterozygous larvae. Cells in homozygous clones in the eye imaginal disc undergo normal photoreceptor differentiation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by

sbb1 is partially rescued by sbbA.GMR.Tag:MYC

Comments

The photoreceptor R1-R6 cell targeting defects of sbb1 mosaics (in which almost all of the eye is homozygous for sbb1 while other tissues are heterozygous) are partially rescued by sbbA.GMR.T:Hsap\MYC; most R1-R6 axons correctly target the lamina, although a small number of R1-R6 axons in each hemisphere, predominantly those in the posterior regions of the eye, still project through the lamina to terminate in the medulla.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that autonomously disrupts the projection patterns of photoreceptor axons from the eye imaginal disc into the optic lobe of the brain.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)