FlyBase Allele Report: Dmel\sbb[04440]

General Information

Symbol

Dmel\sbb⁰⁴⁴⁴⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0008061

Feature type

allele

Associated gene

Dmel\sbb

Associated Insertion(s)

P{PZ}sbb⁰⁴⁴⁴⁰

Carried in Construct

Also Known As

l(2)04440

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}sbb⁰⁴⁴⁴⁰

Cytology

Description

The P{lacW} insertion is within intron 1.

(Rao et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:18,308,104..18,308,104 [+]

(Rao et al., 2000, Senti et al., 2000, Yang et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

lamina plexus

(Rao et al., 2000)

photoreceptor cell R1 & axon | somatic clone (with sbb¹)

(Senti et al., 2000)

photoreceptor cell R1 & axon | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell R1 & neuron

(Rao et al., 2000)

photoreceptor cell R2 & axon | somatic clone (with sbb¹)

(Senti et al., 2000)

photoreceptor cell R2 & axon | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell R2 & neuron

(Rao et al., 2000)

photoreceptor cell R3 & axon | somatic clone (with sbb¹)

(Senti et al., 2000)

photoreceptor cell R3 & axon | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell R3 & neuron

(Rao et al., 2000)

photoreceptor cell R4 & axon | somatic clone (with sbb¹)

(Senti et al., 2000)

photoreceptor cell R4 & axon | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell R4 & neuron

(Rao et al., 2000)

photoreceptor cell R5 & axon | somatic clone (with sbb¹)

(Senti et al., 2000)

photoreceptor cell R5 & axon | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell R5 & neuron

(Rao et al., 2000)

photoreceptor cell R6 & axon | somatic clone (with sbb¹)

(Senti et al., 2000)

photoreceptor cell R6 & axon | somatic clone (with sbb²)

(Senti et al., 2000)

photoreceptor cell R6 & neuron

(Rao et al., 2000)

Detailed Description

Statement

Reference

Third instar larvae homozygous for sbb⁰⁴⁴⁴⁰ displays a significant increase in turning rate during crawling, as compared to controls.

(Suster et al., 2004)

In contrast to the wild-type, in mutant larvae, the lamina plexus is discontinuous. Thick bundles of axons are frequently observed between the lamina and the medulla, in striking contrast to the thin bundles in wild-type. In the most severe cases, the lamina plexus is largely missing and the medulla neuropil is hyperinnervated. In addition, disruptions in the normally smooth topographic map in then medulla are observed. However R-cell projections do not extend through the medulla into deeper layers of the optic lobe, suggesting that R8 neurons terminate, as in wild-type, within the medulla neuropil.

(Rao et al., 2000)

R1-R6 photoreceptor axons overshoot their targets in sbb¹/sbb⁰⁴⁴⁴⁰ or sbb²/sbb⁰⁴⁴⁴⁰ transheterozygous larvae.

(Senti et al., 2000)

Homozygous larvae show significantly more turning behaviour on non-nutritive agar than wild-type larvae ("scribbler" behaviour).

(Yang et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

sbb[+]/sbb⁰⁴⁴⁴⁰ is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

NOT Enhancer of

Statement

Reference

sbb⁰⁴⁴⁴⁰ is a non-enhancer of phenotype of Mer³

(LaJeunesse et al., 2001)

NOT Suppressor of

Statement

Reference

sbb⁰⁴⁴⁴⁰ is a non-suppressor of phenotype of Mer³

(LaJeunesse et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11376

cn¹ P{PZ}sbb⁰⁴⁴⁴⁰/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Phenotypic analysis suggests an allelic series: sbb⁴ >= sbb^k06903b > sbb⁵ = sbb^k00702 > sbb⁰⁴⁴⁴⁰.

(Rao et al., 2000)

Complements: l(2)08770⁰²³⁰². Complements: Hsf⁰³⁰⁹¹. Complements: l(2)04548⁰⁴⁵⁴⁸. Complements: Prp19⁰⁷⁸³⁸. Complements: lolal^k02512. Complements: l(2)08770^k04808. Complements: pAbp^k10109. Complements: Pcl^s1859.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

bks^P3

(Rao et al., 2000)

l(2)04440

(Haecker et al., 2007, LaJeunesse et al., 2001, Senti et al., 2000, Spradling et al., 1999)

l(2)04440⁰⁴⁴⁴⁰

l(2)k04440

(Suster et al., 2004)

sbb⁰⁴⁴⁴⁰

(Kahsai and Cook, 2018, Sarov et al., 2016)

sbb^l(2)04440

(Yang et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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