FlyBase Allele Report: Dmel\par-1[k06821b]

General Information

Symbol

Dmel\par-1^k06821b

Species

D. melanogaster

Name

FlyBase ID

FBal0117401

Feature type

allele

Associated gene

Dmel\par-1

Associated Insertion(s)

P{lacW}mei-W68^k06821b

Carried in Construct

Also Known As

par-1⁶⁸²¹

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Shulman et al., 2000)

Mutagen

P-element activity

(Shulman and McKim, 2000.6.20, Shulman et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{lacW}mei-W68^k06821b

Cytology

Description

P{lacW} insertion in the 5' UTR of the par-1 N1 transcription unit.

(Shulman and McKim, 2000.6.20)

P{lacW} insertion in the 5' UTR sequence that is common between the mei-W68 and N1 class of par-1 transcripts.

(Shulman et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

grandchildless (with par-1^k06323)

(Shulman et al., 2000)

viable (with par-1^k06323)

(Shulman et al., 2000)

Phenotype Manifest In

embryonic abdominal segment (with par-1^k06323)

(Shulman et al., 2000)

embryonic abdominal segment | maternal effect (with par-1^W3)

(Martin and St. Johnston, 2003)

germline cell (with par-1^k06323)

(Shulman et al., 2000)

microtubule & oocyte | posterior

(Shulman et al., 2000)

primordial germ cell (with par-1^k06323)

(Shulman et al., 2000)

ventral denticle belt (with par-1^k06323)

(Shulman et al., 2000)

Detailed Description

Statement

Reference

The progeny of par-1^k06821b/par-1^W3 females show loss of abdominal segments.

(Martin and St. Johnston, 2003)

The progeny of par-1^k06821b/par-1^k06323 females show typical posterior group phenotypes; the embryos may lack abdominal segments (only 73% of embryos and hatched larvae have the wild-type abdominal pattern and the average number of denticle belts is 6.9) and pole cells may fail to form, giving rise to a grandchildless phenotype in which adult escapers have agametic gonads (69/94 of adult escapers have germ cells). Microtubules are found uniformly around the cortex of mutant oocytes, including at the posterior pole, where they are never seen in wild-type oocytes.

(Shulman et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Scer\GAL4^{VP16.mat.αTub67C}, osk^UASp.cZa, par-1^k06323/par-1^k06821b has sterile phenotype

(Zimyanin et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

par-1^k06821b/par-1^W3 has embryonic abdominal segment | maternal effect phenotype, enhanceable by Lkb1^4A4-2

(Martin and St Johnston, 2003)

par-1^k06821b/par-1^W3 has embryonic abdominal segment | maternal effect phenotype, enhanceable by Lkb1^4B1-11

(Martin and St Johnston, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The maternal effect embryonic phenotype of par-1^k06821b/par-1^W3 is enhanced by heterozygosity for lkb1^4B1-11 or lkb1^4A4-2.

(Martin and St Johnston, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: P{lacW}glu^k06821a.

(Shulman and McKim, 2000.6.20)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

l(2)k06821

(Shulman and McKim, 2000.6.20, Shulman et al., 2000)

par-1⁶⁸²¹

(Zimyanin et al., 2007, Zimyanin et al., 2007, Lin et al., 2006, Martin and St. Johnston, 2003, Martin and St Johnston, 2003, Shulman et al., 2000)

par-1^k06821b

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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