FB2026_02 , released June 18, 2026
Allele: Dmel\pimdba.UAS.Tag:MYC
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General Information
Symbol
Dmel\pimdba.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0118073
Feature type
allele
Associated gene
Dmel\pim
Associated Insertion(s)
Carried in Construct
P{UAS-pimdba-myc}
Also Known As
UAS-pimdba-myc
Key Links
Transgenic product class
missense_variant
(Leismann et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Leismann et al., 2000)
Mutagen
in vitro construct
(Leismann et al., 2000)
Progenitor genotype
pimUAS.Tag:MYC
(Leismann et al., 2000)
Carried in construct
P{UAS-pimdba-myc}
Cytology
Description

The pim regulatory region drives expression of pim with a mutated destruction box (KKPLGNLDN changed to AKPAGNLDA).

(Leismann et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
pim
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of pimdba.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4wor.PA results in mitotic catastrophe in larval neuroblasts, including multinucleation and drastically increased cell diameter. Some loss of neuroblasts is seen.

      (Kuang et al., 2014)

      When driven by Scer\GAL4nos.bcd3'UTR.T:Scer\GCN4, pimdba.Scer\UAS.T:Hsap\MYC blocks sister chromatid separation in developing embryos producing diplo-chromosomes. Early divisions are normal, the mitotic spindles are present and the congression of chromosomes to the metaphase is also normal. At the highest levels the abolition of sister chromatid separation appears complete, however at lower levels aberrant anaphase and telophase figures are seen and chromatin bridges are frequent. When pimdba.Scer\UAS.T:Hsap\MYC,Scer\GAL4da.G32 embryos are treated with colcemid during cycle 16, exhibit the presence of diplochromosomes, unlike in controls.

      (Leismann et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pimdba.Scer\UAS.T:Hsap\MYC
      pimdba.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)