FB2026_02 , released June 18, 2026
Allele: Dmel\l(2)gl4w3
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General Information
Symbol
Dmel\l(2)gl4w3
Species
D. melanogaster
Name
FlyBase ID
FBal0118110
Feature type
allele
Associated gene
Dmel\l(2)gl
Associated Insertion(s)
Carried in Construct
Also Known As
lgl4w3
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  carcinoma
        CEA
        (Bilder et al., 2000)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        When l(2)gl4w3 clones are made on the notum, large tumours are seen along with disruptions of junctions between epithelial cells. Within these clones, external sensory organs appear malformed containing additional external cells. Most (84%) mutant external sensory organs consist of three sockets and one hair. Clusters of four sockets are also present at a lower (12%) frequency. Both internal cells are seen to be missing most (96%) of the time.

        (Justice et al., 2003)

        When clones are induced in the wing with the result that the mutant patches affect both wing surfaces wing veins are lost. When the clone only covers one surface of the wing vein differentiation is unaffected. In either case, clones in intervein regions are wild type.

        (Arquier et al., 2001)

        Follicle cell clones show epithelial defects.

        (Bilder et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        l(2)gl4w3/l(2)gl[+] is a non-enhancer of ommatidium phenotype of Vangstbm-153

        (Courbard et al., 2009)
        NOT Suppressor of
        Statement
        Reference

        l(2)gl4w3/l(2)gl[+] is a non-suppressor of ommatidium phenotype of Vangstbm-153

        (Courbard et al., 2009)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Heterozygosity for l(2)gl4w3 has no effect on the frequency of ommatidia that show planar cell polarity defects in Vangstbm-153 homozygotes.

        (Courbard et al., 2009)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer

        Selected as: a mutation that causes epithelial defects in follicle cell clones.

        (Bilder et al., 2000)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        References (9)