FlyBase Allele Report: Dmel\Vang[stbm-153]

General Information

Symbol

Dmel\Vang^stbm-153

Species

D. melanogaster

Name

FlyBase ID

FBal0088604

Feature type

allele

Associated gene

Dmel\Vang

Associated Insertion(s)

Carried in Construct

Also Known As

stbm¹⁵³, Vang¹⁵³

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Wolff and Rubin, 1998)

Progenitor genotype

Cytology

Description

7bp deletion starting at nucleotide 614, causing a frameshift at amino acid 205.

(Wolff and Rubin, 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:9,104,247..9,104,253 [+]

Comment:

Reported to be a 7bp deletion starting at nucleotide 614 causing a frame shift at aa 205; position of mutation on reference sequence inferred by FlyBase curator (using A of ATG of GB:AF044208 as position 1).

(Wolff and Rubin, 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Courbard et al., 2009, Rawls et al., 2007, Rawls and Wolff, 2003)

lethal - all die during embryonic stage | maternal effect | partially

(Lee et al., 2003)

lethal - all die during embryonic stage | partially (with Vang^stbm-7-6)

(Lee et al., 2003)

some die during embryonic stage | partially

(Lee et al., 2003)

some die during embryonic stage | partially (with Vang^stbm-7-6)

(Lee et al., 2003)

Phenotype Manifest In

embryo | maternal effect

(Lee et al., 2003)

embryo | maternal effect (with Vang^stbm-7-6)

(Lee et al., 2003)

ommatidium

(Courbard et al., 2009, Fetting et al., 2009, Rawls et al., 2007, Rawls and Wolff, 2003)

Detailed Description

Statement

Reference

38 +/- 6.9% of ommatidia show defects in planar cell polarity in homozygotes.

(Courbard et al., 2009)

Many Vang^stbm-153 ommatidia over- or under-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes.

(Fetting et al., 2009)

Homozygotes show defects in ommatidial polarity.

(Rawls et al., 2007)

20% of Vang^stbm-153 homozygous embryos fail to hatch, exhibiting a phenotype similar to unfertilized eggs. 81% of Vang^stbm-7-6/Vang^stbm-153 embryos fail to hatch, exhibiting a phenotype similar to unfertilized eggs. Approximately 23% of Vang^stbm-7-6/Vang^stbm-153 embryos are capable of reaching the 2-5 hour stage of development.

(Lee et al., 2003)

Homozygotes exhibit a range of polarity defects in the eye. 39.8% of ommatidia show polarity defects.

(Rawls and Wolff, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Vang^stbm-153 has abnormal planar polarity phenotype, enhanceable by scrib[+]/scrib⁶⁷³

(Courbard et al., 2009)

Vang^stbm-153 has abnormal planar polarity phenotype, enhanceable by scrib[+]/scrib¹

(Courbard et al., 2009)

Vang^stbm-153 has abnormal planar polarity phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

Vang^stbm-153 has abnormal planar polarity phenotype, enhanceable by stan^frz3

(Rawls and Wolff, 2003)

Vang^stbm-153 has abnormal planar polarity phenotype, enhanceable by pk¹

(Rawls and Wolff, 2003)

Enhancer of

Statement

Reference

Vang^stbm-153 is an enhancer of abnormal planar polarity phenotype of stan^frz3

(Rawls and Wolff, 2003)

NOT Enhancer of

Statement

Reference

Vang^stbm-153/Vang[+] is a non-enhancer of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Vang^stbm-153/Vang[+] is a non-enhancer of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

Vang^stbm-153/Vang[+] is a non-suppressor of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Vang^stbm-153/Vang[+] is a non-suppressor of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

Vang^stbm-153 has ommatidium phenotype, enhanceable by scrib[+]/scrib⁶⁷³

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, enhanceable by scrib[+]/scrib¹

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

Vang^stbm-153 has ommatidium phenotype, enhanceable by stan^frz3

(Rawls and Wolff, 2003)

Vang^stbm-153 has ommatidium phenotype, enhanceable by pk¹

(Rawls and Wolff, 2003)

NOT Enhanced by

Statement

Reference

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by dlg1[+]/dlg1¹⁴

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by dlg1[+]/dlg1¹⁸

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by dlg1[+]/dlg1¹³

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by dlg1[+]/dlg1^w55

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by l(2)gl^4w3/l(2)gl[+]

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by par-6[+]/par-6^Δ226

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by baz⁴/baz[+]

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-enhanceable by sdt^XP/sdt[+]

(Courbard et al., 2009)

Suppressed by

Statement

Reference

Vang^stbm-153 has ommatidium phenotype, suppressible by fred[+]/fred^H24

(Fetting et al., 2009)

NOT suppressed by

Statement

Reference

Vang^stbm-153 has ommatidium phenotype, non-suppressible by sdt^XP/sdt[+]

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-suppressible by dlg1[+]/dlg1¹⁴

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-suppressible by dlg1[+]/dlg1¹⁸

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-suppressible by dlg1[+]/dlg1¹³

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-suppressible by dlg1[+]/dlg1^w55

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-suppressible by l(2)gl^4w3/l(2)gl[+]

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-suppressible by par-6[+]/par-6^Δ226

(Courbard et al., 2009)

Vang^stbm-153 has ommatidium phenotype, non-suppressible by baz⁴/baz[+]

(Courbard et al., 2009)

Enhancer of

Statement

Reference

Vang^stbm-153 is an enhancer of ommatidium phenotype of stan^frz3

(Rawls and Wolff, 2003)

NOT Enhancer of

Statement

Reference

Vang^stbm-153/Vang[+] is a non-enhancer of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

Vang^stbm-153/Vang[+] is a non-suppressor of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Other

Statement

Reference

Vang^stbm-153, stan^frz3 has photoreceptor neuron phenotype

(Rawls and Wolff, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for scrib¹ or scrib⁶⁷³ enhances the frequency of ommatidia that show planar cell polarity defects in Vang^stbm-153 homozygotes.

Heterozygosity for dlg1¹⁴, dlg1¹⁸, dlg1¹³, dlg1^w55, l(2)gl^4w3, par-6^Δ226, baz⁴ or sdt^XP has no effect on the frequency of ommatidia that show planar cell polarity defects in Vang^stbm-153 homozygotes.

(Courbard et al., 2009)

fred^H24 dominantly suppresses the phenotype of mis-rotation of ommatidia that is seen in Vang^stbm-153 animals.

(Fetting et al., 2009)

Homozygosity for bdg¹⁶⁴ enhances the ommatidial polarity defects caused by homozygosity for Vang^stbm-153.

(Rawls et al., 2007)

32.9% of ommatidia in stan^frz3/stan^frz3, Vang^stbm-153/+ animals exhibit polarity defects in the eye. 63.7% of ommatidia in stan^frz3/stan^frz3, Vang^stbm-153/Vang^stbm-153 animals exhibit polarity defects in the eye. They also have missing photoreceptor cells. 49.7% of ommatidia in pk¹/pk¹, Vang^stbm-153/Vang^stbm-153 animals exhibit polarity defects in the eye.

(Rawls and Wolff, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Vang^stbm-153 is partially rescued by Vang^ΔPBM.cCa

(Courbard et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6919

Vang^stbm-153/CyO, P{sevRas1.V12}FK1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Vang¹⁵³

(Payankaulam et al., 2022, Kelly et al., 2016)

Vang^stbm-153

(Payankaulam et al., 2022)

stbm-153

(Lee et al., 2003)

stbm¹⁵³

(Courbard et al., 2009, Fetting et al., 2009, Rawls et al., 2007, Cho, 2004, Rawls and Wolff, 2003, Wolff and Rubin, 1998)

vang^stbm-153

(Han et al., 2020)

vang^stbm153

(Lee et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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