FlyBase Allele Report: Dmel\cib[P]

General Information

Symbol

Dmel\cib^P

Species

D. melanogaster

Name

FlyBase ID

FBal0118296

Feature type

allele

Associated gene

Dmel\cib

Associated Insertion(s)

P{GawB}cib^P

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Boquet et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{GawB}cib^P

Cytology

Description

Insert stated as cause: P{GAL4} P{GAL4} insertion in cib.

(Boquet et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Boquet et al., 2000, Boquet et al., 2000)

viable (with Df(1)A113)

(Boquet et al., 2000)

Phenotype Manifest In

ellipsoid body

(Boquet et al., 2000, Boquet et al., 2000)

ellipsoid body (with Df(1)A113)

(Boquet et al., 2000)

Detailed Description

Statement

Reference

Flies have a mutant ellipsoid body.

(Boquet et al., 2000)

When originally isolated, homozygous adults had a ventrally opened ellipsoid body in the central brain with strong penetrance. The penetrance became very strong after 5 generations of outcrossing. cib^P/Df(1)A113 flies have an opened ellipsoid body with very high frequency. Heterozygotes have no adult central brain defect.

(Boquet et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

chic²²¹, cib^P has visible phenotype

(Boquet et al., 2000)

chic²²¹, cib^P has sterile phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has visible phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has sterile phenotype

(Boquet et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

cib^P has ellipsoid body phenotype, enhanceable by chic[+]/chic²²¹

(Boquet et al., 2000)

Other

Statement

Reference

chic²²¹, cib^P has fan-shaped body phenotype

(Boquet et al., 2000)

chic²²¹, cib^P has adult thorax & chaeta phenotype

(Boquet et al., 2000)

chic²²¹, cib^P has mushroom body medial lobe phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has fan-shaped body phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has adult thorax & chaeta phenotype

(Boquet et al., 2000)

chic[+]/chic²²¹, cib^P has mushroom body medial lobe phenotype

(Boquet et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

cib^P/+ ; chic²²¹/+ double heterozygotes show a cib-like mutant phenotype, with a partially split fan-shaped body (it is split along the midline in 10% of flies), a ventrally opened ellipsoid body and a normal mushroom body. This interaction is synergistic. Addition of chic²²¹ to cib^P/Y flies exacerbates the cib^P phenotype; cib^P/Y ; chic²²¹/+ males have a fan-shaped body that is split in the middle, a strongly disturbed ellipsoid body (it is flat and very often split along the midline) and disorganised mushroom body medial lobes that rarely reach their normal position. cib^P/Y ; chic²²¹/+ males are also sterile and show a thoracic bristle defect with shorter and forked ends than normal.

(Boquet et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

cib^P is not rescued by cib^hs.PB

(Boquet et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9464

w¹¹¹⁸ P{GawB}cib^P

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cib^P1

(Thran et al., 2013)

cib^P

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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