FlyBase Allele Report: Dmel\Dronc[GMR.PH]

General Information

Symbol

Dmel\Dronc^GMR.PH

Species

D. melanogaster

Name

glass multimer reporter construct of Hawkins

FlyBase ID

FBal0119455

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

P{GMR-Dronc.H}

Also Known As

GMR-Dronc

Key Links

Transgenic product class

wild_type

(Hawkins et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Hawkins et al., 2000)

Mutagen

in vitro construct

(Hawkins et al., 2000)

Progenitor genotype

Carried in construct

P{GMR-Dronc.H}

Cytology

Description

GMR regulatory sequences drive expression of full length wild-type Dronc.

(Hawkins et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Dronc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Hawkins et al., 2000)

visible

(Copeland et al., 2007, Huh et al., 2007, Hawkins et al., 2000)

Phenotype Manifest In

eye

(Copeland et al., 2007, Huh et al., 2007, Hawkins et al., 2000)

eye photoreceptor cell

(Hawkins et al., 2000)

pigment cell

(Hawkins et al., 2000)

retina

(Muro et al., 2006, Hawkins et al., 2000)

Detailed Description

Statement

Reference

The eyes of flies that express Nc^GMR.PH show retinal degeneration.

(Muro et al., 2006)

Expression of Nc^GMR.PH does not cause retinal degeneration.

(Hsu et al., 2004)

Flies expressing Nc^GMR.PH have normal eye morphology.

(Yu et al., 2002)

Flies expressing different lines of Nc^GMR.PH show various degrees of eye disruption. Flies expressing low levels of Nc^GMR.PH show no outward phenotype. Flies expressing intermediate levels of Nc^GMR.PH show cell death late in retinal development. The eyes are normal in size and shape, but are largely white due to loss of retinal pigment. All retinal cells, including photoreceptors, are missing. Flies expressing even higher levels of Nc^GMR.PH have small eyes and third larval instar eye imaginal discs of these animals show high levels of cell death.

(Hawkins et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dronc^GMR.PH has visible phenotype, enhanceable by Diap1⁵/th[+]

(Hawkins et al., 2000)

NOT Enhanced by

Statement

Reference

Dronc^GMR.PH has visible phenotype, non-enhanceable by ec^EPΔ4

(Copeland et al., 2007)

Dronc^GMR.PH has visible phenotype, non-enhanceable by ec^SF1.GMR

(Copeland et al., 2007)

Suppressed by

Statement

Reference

Dronc^GMR.PH has abnormal eye color phenotype, suppressible by Diap1^GMR.PH

(Hawkins et al., 2000)

Dronc^GMR.PH has visible phenotype, suppressible by Diap1^GMR.PH

(Hawkins et al., 2000)

NOT suppressed by

Statement

Reference

Dronc^GMR.PH has visible phenotype, non-suppressible by ec^SF1.GMR

(Copeland et al., 2007)

Dronc^GMR.PH has visible phenotype, non-suppressible by ec^EPΔ4

(Copeland et al., 2007)

Dronc^GMR.PH has visible phenotype, non-suppressible by Diap2^GMR.PH

(Huh et al., 2007)

Dronc^GMR.PH has visible phenotype, non-suppressible by BacA\p35^GMR.PH

(Hawkins et al., 2000)

Suppressor of

Statement

Reference

Dronc^GMR.PH is a suppressor of increased cell death phenotype of norpA^P24

(Hsu et al., 2004)

NOT Suppressor of

Statement

Reference

Dronc^GMR.PH is a non-suppressor of visible phenotype of BacA\p35^GMR.PH

(Yu et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dronc^GMR.PH has eye phenotype, enhanceable by Diap1⁵/th[+]

(Hawkins et al., 2000)

NOT Enhanced by

Statement

Reference

Dronc^GMR.PH has eye phenotype, non-enhanceable by ec^EPΔ4

(Copeland et al., 2007)

Dronc^GMR.PH has eye phenotype, non-enhanceable by ec^SF1.GMR

(Copeland et al., 2007)

Suppressed by

Statement

Reference

Dronc^GMR.PH has eye phenotype, suppressible by mir-14^GMR.PX

(Xu et al., 2003)

Dronc^GMR.PH has eye phenotype, suppressible by Diap1^GMR.PH

(Hawkins et al., 2000)

Dronc^GMR.PH has pigment cell phenotype, suppressible by Diap1^GMR.PH

(Hawkins et al., 2000)

NOT suppressed by

Statement

Reference

Dronc^GMR.PH has eye phenotype, non-suppressible by ec^EPΔ4

(Copeland et al., 2007)

Dronc^GMR.PH has eye phenotype, non-suppressible by ec^SF1.GMR

(Copeland et al., 2007)

Dronc^GMR.PH has eye phenotype, non-suppressible by Diap2^GMR.PH

(Huh et al., 2007)

Dronc^GMR.PH has retina phenotype, non-suppressible by Drice^Δ1

(Muro et al., 2006)

Dronc^GMR.PH has eye phenotype, non-suppressible by BacA\p35^GMR.PH

(Hawkins et al., 2000)

Suppressor of

Statement

Reference

Dronc^GMR.PH is a suppressor of retina phenotype of norpA^P24

(Hsu et al., 2004)

NOT Suppressor of

Statement

Reference

Dronc^GMR.PH is a non-suppressor of ommatidium phenotype of BacA\p35^GMR.PH

(Yu et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

An Ice^Δ1 background does not significantly suppress the retinal degeneration phenotype of Nc^GMR.PH flies.

(Muro et al., 2006)

Expression of Nc^GMR.PH in norpA³⁶ retinae slows down retinal degeneration but does not prevent it.

(Hsu et al., 2004)

The rough eye phenotype of BacA\p35^GMR.PH animals is not suppressed by Nc^GMR.PH. Flies expressing Nc^GMR.PH and th^GMR.PH have normal eye morphology.

(Yu et al., 2002)

Flies expressing intermediate levels of Nc^GMR.PH and also heterozygous for th⁵ have small eyes. The small eye and pigment loss phenotypes of flies expressing high levels of Nc^GMR.PH is suppressed by co-expression of th^GMR.PH. The small eye phenotype of flies expressing high levels of Nc^GMR.PH is not significantly suppressed by co-expression of BacA\p35^GMR.PH.

(Hawkins et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dronc^GMR.PH

Nc^GMR.PH

Name Synonyms

glass multimer reporter construct of Hawkins

(Hawkins et al., 2000)

Secondary FlyBase IDs

References (8)

Report Sections

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