FlyBase Allele Report: Dmel\Dronc[C318S.GMR]

General Information

Symbol

Dmel\Dronc^C318S.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0119456

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

P{GMR-Dronc.C318S}

Key Links

Transgenic product class

missense_variant

(Hawkins et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Hawkins et al., 2000)

Mutagen

in vitro construct

(Hawkins et al., 2000)

Progenitor genotype

Carried in construct

P{GMR-Dronc.C318S}

Cytology

Description

GMR regulatory sequences drive expression of a mutated form of Dronc (carries the amino acid replacement C318S).

(Hawkins et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Dronc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Nc^C318S.GMR suppresses the cone cell changes seen when animals are exposed to UV irradiation.

(Jassim et al., 2003)

Flies expressing Nc^C318S.GMR have normal eye morphology.

(Yu et al., 2002)

The eyes of flies expressing Nc^C318S.GMR appear similar to wild type.

(Hawkins et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dronc^C318S.GMR is a suppressor of visible phenotype of BacA\p35^GMR.PH

(Yu et al., 2002)

Dronc^C318S.GMR is a suppressor | partially of increased cell death phenotype of Scer\GAL4^GMR.PF, rpr^C.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, rpr^C.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, grim^C.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of lethal phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of lethal phenotype of Scer\GAL4^GMR.PF, grim::rpr^gr.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, grim::rpr^gr.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor | partially of increased cell death phenotype of Scer\GAL4^GMR.PF, grim^C.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of visible phenotype of hid^GMR.PH

(Hawkins et al., 2000)

Dronc^C318S.GMR is a suppressor of visible phenotype of grim^GMR.PH

(Hawkins et al., 2000)

Dronc^C318S.GMR is a suppressor of visible phenotype of rpr^GMR.PH

(Hawkins et al., 2000)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dronc^C318S.GMR is a suppressor of ommatidium phenotype of BacA\p35^GMR.PH

(Yu et al., 2002)

Dronc^C318S.GMR is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, grim^C.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, rpr^C.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, grim::rpr^gr.UAS

(Wing et al., 2001)

Dronc^C318S.GMR is a suppressor of eye phenotype of hid^GMR.PH

(Hawkins et al., 2000)

Dronc^C318S.GMR is a suppressor of eye phenotype of grim^GMR.PH

(Hawkins et al., 2000)

Dronc^C318S.GMR is a suppressor of eye phenotype of rpr^GMR.PH

(Hawkins et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype of BacA\p35^GMR.PH animals is suppressed by Nc^C318S.GMR. Flies expressing Nc^C318S.GMR and th^GMR.PH have normal eye morphology.

(Yu et al., 2002)

Co-expression of Nc^C318S.GMR suppresses the W^GMR.PH, rpr^GMR.PH or grim^GMR.PH small eye phenotypes.

(Hawkins et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dronc^C318S.GMR

Nc^C318S.GMR

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close