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General Information
Symbol
Dmel\fumH63
Species
D. melanogaster
Name
FlyBase ID
FBal0120493
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G18658350A

Reported nucleotide change:

G1414A

Amino acid change:

A147T | fu-PA

Reported amino acid change:

A147T

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: A147T. Residue is located 2 positions downstream of the DFG triplet.

Amino acid replacement: A?T. Mutation is in the kinase domain.

restriction map normal

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Polar follicle cell specification occurs in clones induced in somatic stem cells and their descendents. Relatively large somatic clones that include the anterior region of the follicular epithelium of an egg chamber are associated with the production of egg chambers with abnormal numbers of germline cells.

Germ cells in embryos lacking maternal fu function (derived from females carrying fumH63 germline clones and fertilised with a wild-type sperm) migrate towards the somatic gonadal precursor cells but fail to properly associate with them and instead scatter through the posterior half of the embryo. These embryos do not hatch.

Mutant embryos derived from homozygous germline clones lack Bolwig's organs.

fumH63 mutant clones at the AP border of the wing invade posterior compartment territory and induce a central vein 3 decorated with sensillae at the position normally occupied by vein 4. Wing morphology is not affected in clones outside the region usually affected by hh signalling.

Homozygotes display a strong fu wing phenotype.

Pharates die with a strong fused wing phenotype.

Homozygous and hemizygous females and hemizygous males die in pupal stage; lethality suppressible by Su(fu). fumH63/fu41 and fumH63/Y have all segments entirely duplicated; lack mouth hooks and some have no head. fumH63/+ embryos from such clones exhibit very low paternal rescue; small correction of segmental phenotype, low hatch and preadult mortality (Busson et al. 1988). pupal lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

fumH63 has phenotype, suppressible | partially by Su(fu)LP

fumH63 has phenotype, suppressible by Su(fu)12d

fumH63 has phenotype, suppressible by Su(fu)LP

Enhancer of
Statement
Reference

fumH63 is an enhancer of wing phenotype of ptcS2

fumH63 is an enhancer of wing vein phenotype of ptcS2

NOT Enhancer of
Statement
Reference

fumH63 is a non-enhancer of wing phenotype of Pka-C1B3

NOT Suppressor of
Statement
Reference

fumH63 is a non-suppressor of wing phenotype of Pka-C1B3

Additional Comments
Genetic Interactions
Statement
Reference

The lack of Bolwig's organs seen in embryos derived from homozygous germline is partially rescued by expression of hhScer\UAS.cKa under the control of Scer\GAL4da.G32.

Somatic stem cell clones in the ovary homozygous for both fumH63 and ptcS2 show only very mild overproliferation.

Wing phenotype of Pka-C1B3 mutant clones is unaffected by fumH63. ptcS2, fumH63 double mutant clones still retain some pattern organising activity in wings.

When in combination with Su(fu)LP heterozygotes individuals display a partially suppressed fu phenotype. When in combination with cos3 individuals display no cos phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Lethality is rescued when in combination with either fu+t5.1 or fu+t7.4, individuals display wild type wings.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Hanratty.

Comments
Comments

Class I fu allele.

Class I mutation based on interaction with Su(fu)LP, suppression of embryonic and adult phenotype.

External Crossreferences and Linkouts ( 2 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
Synonyms and Secondary IDs (5)
References (26)