FlyBase Allele Report: Dmel\Rab7[Q67L.UAS]

General Information

Symbol

Dmel\Rab7^Q67L.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0120654

Feature type

allele

Associated gene

Dmel\Rab7

Associated Insertion(s)

Carried in Construct

P{UAS-Rab7.Q67L}

Also Known As

UAS-Rab7-CA, UAS-Rab7^ca

Key Links

Transgenic product class

gain_of_function_variant

(Entchev et al., 2000)

missense_variant

(Entchev et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

gain_of_function_variant

(Entchev et al., 2000)

missense_variant

(Entchev et al., 2000)

Mutagen

in vitro construct

(Entchev et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Rab7.Q67L}

Cytology

Description

UAS regulatory sequences drive expression of a dominant gain-of-function form of Rab7.

(Entchev et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Rab7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^en-e16E

(Entchev et al., 2000)

Phenotype Manifest In

autophagosome | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Lőrincz et al., 2017)

embryonic/larval fat body | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Lőrincz et al., 2017)

wing blade posterior compartment, with Scer\GAL4^en-e16E

(Entchev et al., 2000)

Detailed Description

Statement

Reference

Expression of Rab7^{Q67L.Scer\UAS} under the control of Scer\GAL4^Act.PU in clones of larval fat body cells does not increase the size of autophagic structures compared to the surrounding control cells.

(Lőrincz et al., 2017)

Expression of Rab7^{Q67L.Scer\UAS} in border cells, driven by Scer\GAL4^slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte.

(Medioni and Noselli, 2005)

Expression of Rab7^{Q67L.Scer\UAS} under the control of Scer\GAL4^en-e16E results in compression of the anterior/posterior axis of the posterior but not the anterior compartment of the wing.

(Entchev et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^pnt-14-94/Rab7^Q67L.UAS is a suppressor of increased cell number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Scer\GAL4^insc-Mz1407/Rab7^Q67L.UAS is a suppressor of increased cell number | larval stage phenotype of Vps35^E42