FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DreddF64
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General Information
Symbol
Dmel\DreddF64
Species
D. melanogaster
Name
FlyBase ID
FBal0120962
Feature type
allele
Associated gene
Dmel\Dredd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Leulier, 2019.9.22, Leulier et al., 2000)
Mutagen
ethyl methanesulfonate
(Leulier et al., 2000)
Progenitor genotype
Cytology
Description

C to T substitution at genomic position X:633735 , which creates a premature codon (CAG, glutamine, Q, to TAG, STOP) that removes the last 8 amino acids of the Dredd protein, affecting the caspase-8 subunit p10 domain. (Revision of data reported in FBrf0133276).

(Leulier, 2019.9.22)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_alteration
X:633,735..633,735 [-]
Nucleotide change:

C633735T

Amino acid change:

Q480term | Dredd-PD; Q486term | Dredd-PE; Q432term | Dredd-PG

Reported amino acid change:

Q?term

Comment:

The point mutation creates a premature stop codon that removes the last eight amino acids of the Dredd protein.

(Leulier, 2019.9.22)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      DreddF64 homozygotes do not exhibit a significant proportion of hyperplastic testes, as compared to controls.

      (Napoletano et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      DreddF64/DreddF64 is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Moreno et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygosity for DreddF64 does not supress the ablation of adult eye tissue seen in egrScer\UAS.cMa; Scer\GAL4GMR.PF animals.

      (Moreno et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DreddF64
      (Charroux and Royet, 2022, Suissa et al., 2011)
      F64
      (Leulier, 2019.9.22, Leulier et al., 2000)
      dreddF64
      (Napoletano et al., 2017, Moreno et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)