FlyBase Allele Report: Dmel\msk[2]

General Information

Symbol

Dmel\msk²

Species

D. melanogaster

Name

FlyBase ID

FBal0122950

Feature type

allele

Associated gene

Dmel\msk

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Baker et al., 2002)

Progenitor genotype

Cytology

Description

Extra nucleotide (C) inserted after position A559, resulting in a frameshift after codon L184 leading to a stop codon after residue 235.

(Baker et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

insertion

3L:8,117,828..8,117,829 [+]

Comment:

A "C" residue is inserted after nucleotide A559 of the msk CDS. This leads to a frameshift after amino acid L186 and a stop codon after residue 238. It is reported as a C insertion at A559 leading to a frameshift after L184 and a stop codon after residue 235 but this does match the reference sequence.

Inserted_sequence:

(Baker et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | recessive

(Baker et al., 2002)

lethal | larval stage | recessive

(Baker et al., 2002)

lethal | recessive

(Lorenzen et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes die as late embryos or early larvae, with a normal looking cuticle.

(Baker et al., 2002)

Lethality acts in the late embryo or early larval stages. Embryos are morphologically wild type.

(Lorenzen et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

msk[+]/msk² is an enhancer of visible phenotype of rl¹

(Lorenzen et al., 2001)

Suppressor of

Statement

Reference

msk[+]/msk² is a suppressor of visible phenotype of Scer\GAL4^c684, if^m8.UAS

(Baker et al., 2002)

msk[+]/msk² is a suppressor of visible phenotype of rl^Sem

(Lorenzen et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

msk[+]/msk² is an enhancer of wing vein L4 phenotype of rl¹

(Lorenzen et al., 2001)

Suppressor of

Statement

Reference

msk[+]/msk² is a suppressor of wing phenotype of Scer\GAL4^c684, if^m8.UAS

(Baker et al., 2002)

msk[+]/msk² is a suppressor of wing vein | ectopic phenotype of rl^Sem

(Lorenzen et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The wing blistering caused by expression of if^m8.Scer\UAS under the control of Scer\GAL4^337Y is suppressed by msk²/+.

(Baker et al., 2002)

Enhancing effect of msk¹ and msk² on the rl¹ phenotype is marked and that of msk⁵ is dramatic.

(Lorenzen et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant suppressor of the wing blister phenotype caused by if^m8.Scer\UAS expressed under the control of Scer\GAL4^c684. "msk²" and "msk³" alleles isolated in the same screen and are duplicates of the same mutation.

(Baker et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

msk²

msk³

(Baker et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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