FlyBase Allele Report: Dmel\drk[EP2477]

General Information

Symbol

Dmel\drk^EP2477

Species

D. melanogaster

Name

FlyBase ID

FBal0122997

Feature type

allele

Associated gene

Dmel\drk

Associated Insertion(s)

P{EP}drk^EP2477

Carried in Construct

Also Known As

Drk^EP(2)2477, EP(2)2477, mars^P

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, FlyBase, 1996-)

Progenitor genotype

Associated Insertion(s)

P{EP}drk^EP2477

Cytology

Description

The P{EP} element is inserted 526 nucleotides 5' to the predicted ATG start codon.

(Kraut et al., 2001)

The P{EP}drk^EP2477 insertion maps within mars. The insertion is also just upstream of drk, in the right orientation to drive overexpression of drk in the presence of a Scer\GAL4 driver.

(FlyBase, 1996-)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:13,503,016..13,503,016 [-]

(Almudi et al., 2010, Almudi et al., 2009, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Phenotype Manifest In

anterior fascicle & synapse | supernumerary, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Detailed Description

Statement

Reference

Mutant larvae expressing drk^EP2477 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects. Mutant larvae expressing drk^EP2477 under the control of Scer\GAL4^elav-C155 have excessive or ectopic synapses.

(Kraut et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

drk^EP2477/Scer\GAL4^hs.2sev is an enhancer of visible phenotype of Scer\GAL4^hs.2sev, sev^S11.Tag:MYC

(Almudi et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

drk^EP2477/Scer\GAL4^hs.2sev is an enhancer of eye phenotype of sev^S11.Tag:MYC

(Almudi et al., 2010)

drk^EP2477/Scer\GAL4^hs.2sev is an enhancer of eye phenotype of Scer\GAL4^hs.2sev, sev^S11.Tag:MYC

(Almudi et al., 2009)

drk^EP2477/Scer\GAL4^hs.2sev is an enhancer of photoreceptor cell R7 | increased number phenotype of Scer\GAL4^hs.2sev, sev^S11.Tag:MYC

(Almudi et al., 2009)

Other

Statement

Reference

Scer\GAL4^hs.2sev, Socs36E^UASp.cCa, drk^EP2477, sev^S11.Tag:MYC has eye phenotype

(Almudi et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of drk^EP2477 under the control of Scer\GAL4^hs.2sev in a sev^{S11.T:Hsap\MYC} genetic background results in a strong rough eye phenotype.

Expression of drk^EP2477 and Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev in a sev^{S11.T:Hsap\MYC} genetic background results in an intermediate rough-eye phenotype.

(Almudi et al., 2010)

Expression of drk^EP2477 under the control of Scer\GAL4^hs.2sev enhances the rough eye and extra R7 photoreceptor cell phenotype caused by sev^{S11.T:Hsap\MYC}.

(Almudi et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Drk^EP(2)2477

(Almudi et al., 2009)

drk^EP2477

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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