FlyBase Allele Report: Dmel\lncRNA:flam[py+P]

General Information

Symbol

Dmel\lncRNA:flam^py+P

Species

D. melanogaster

Name

FlyBase ID

FBal0123859

Feature type

allele

Associated gene

Dmel\lncRNA:flam

Associated Insertion(s)

P{lyB}lncRNA:flam^py+P

Carried in Construct

Also Known As

flam^py+(P)

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Robert et al., 2001)

Progenitor genotype

lncRNA:flam^FM7c

(Robert et al., 2001)

Associated Insertion(s)

P{lyB}lncRNA:flam^py+P

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lyB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile (with lncRNA:flam^EY7P)

(Mevel-Ninio et al., 2007)

female semi-sterile (with lncRNA:flam^KG00476)

(Mevel-Ninio et al., 2007)

female sterile (with lncRNA:flam^BG02658)

(Mevel-Ninio et al., 2007)

female sterile | heat sensitive

(Mevel-Ninio et al., 2007)

Phenotype Manifest In

egg chamber

(Mevel-Ninio et al., 2007)

nurse cell

(Mevel-Ninio et al., 2007)

ovary

(Mevel-Ninio et al., 2007)

Detailed Description

Statement

Reference

Homozygous females do not lay any eggs. Partial rescue of the female sterile phenotype is seen if the third larval instar and pupal stages are raised at 18^oC rather than at 22^oC.

flam^py+P flies have a permissive phenotype with respect to gypsy expression (assayed by expression of a P{gypsy-lacZ.p12} reporter construct in the ovaries).

flam^py+P flies are unstable for ZAM expression (assayed by expression of a P{ZAM-lacZ.LTR} reporter construct in the ovaries).

Mutant females often show abnormalities during ovarian development. Compound egg chambers as well as egg chambers with a deficit in nurse cell number are seen.

(Mevel-Ninio et al., 2007)

Recessive permissive flam allele.

(Robert et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

lncRNA:flam^py+P has female sterile phenotype, non-suppressible by DIP1^t8

(Mevel-Ninio et al., 2007)

lncRNA:flam^py+P has female sterile phenotype, non-suppressible by DIP1^cos7a

(Mevel-Ninio et al., 2007)

lncRNA:flam^py+P has female sterile phenotype, non-suppressible by DIP1^b.hs

(Mevel-Ninio et al., 2007)

lncRNA:flam^py+P has female sterile phenotype, non-suppressible by DIP1^c.hs

(Mevel-Ninio et al., 2007)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

lncRNA:flam^EY7P

(Mevel-Ninio et al., 2007)

lncRNA:flam^KG00476

(Mevel-Ninio et al., 2007)

Fails to complement

lncRNA:flam^BG02658

(Mevel-Ninio et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

53721

C(1)DX, y¹ f¹/FM7c, sn⁺ P{lyB}lncRNA:flam^py+P

Notes on Origin

Discoverer

Comments

Excision of the P{lyB} insertion in flam^py+P can revert the female sterile phenotype (in these cases there is simultaneous reversion towards the restrictive flam character).

(Mevel-Ninio et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

flam^py+(P)

(Mevel-Ninio et al., 2007, Nefedova et al., 2007, Robert et al., 2001)

flam^py+P

lncRNA:flam^py+P

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close