FB2026_02 , released June 18, 2026
Allele: Dmel\Hsc70-4Δ11
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General Information
Symbol
Dmel\Hsc70-4Δ11
Species
D. melanogaster
Name
FlyBase ID
FBal0124179
Feature type
allele
Associated gene
Dmel\Hsc70-4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Bronk et al., 2001)
Mutagen
P-element activity
(Bronk et al., 2001)
Progenitor genotype
Hsc70-403550
(Bronk et al., 2001)
Caused by aberration
Df(3R)Hsc70-4Δ11
Cytology
Description

Df(3R)Hsc70-4Δ11 has a breakpoint within the first intron of the Hsc70-4 gene. Deletion spans -813 to +853.

(Bronk et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:15,241,876..15,243,541 [+]
Comment:

Imprecise excision of the EP(3)0859 P-element, deleting 1666 nucleotides, including the promoter and first exon of Hsc70-4. Position of mutation on reference sequence inferred by FlyBase curator.

(Bronk et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae show sporadic but reduced muscle contractions. The quantal content of evoked release in homozygotes and Hsc70-4Δ19/Hsc70-4Δ11 transheterozygotes is reduced to a third to a half of control. The EJP amplitudes recorded from mutant neuromuscular junctions (NMJs) are reduced to about 3/4 of control amplitudes.

      (Bronk et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Hsc70-4Δ11 has axon | larval stage phenotype, enhanceable by CspX1

      (Bronk et al., 2001)
      Enhancer of
      Statement
      Reference

      Hsc70-4Δ11 is an enhancer of axon | larval stage phenotype of CspX1

      (Bronk et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The EJP amplitudes recorded from Hsc70-4Δ11, CspX1 double mutant neuromuscular junctions (NMJs) are reduced to about 1/2 of control amplitudes.

      (Bronk et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsc70-4Δ11
      Name Synonyms
      Secondary FlyBase IDs
        References (2)