FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tsh8.1
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General Information
Symbol
Dmel\tsh8.1
Species
D. melanogaster
Name
FlyBase ID
FBal0124919
Feature type
allele
Associated gene
Dmel\tsh
Associated Insertion(s)
P{PZ}tsh8.1
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Soanes et al., 2001)
Mutagen
P-element activity
(Soanes et al., 2001)
Progenitor genotype
tsh04319
(Soanes et al., 2001)
Associated Insertion(s)
P{PZ}tsh8.1
Cytology
Description

In addition to the intact P{PZ} insertion is a deletion that removes the immediate 3' flanking sequence, including all of the tsh coding region.

(Soanes et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes for tshae-1 and tsh8.1 show the characteristic abnormal wing and haltere posture, as found in tshae-1 mutants, but the phenotypes also include a number of other thoracic and wing-hinge defects, much like those observed with tsh8. In heterozygotes for tshae-1 and tsh8.1, it appears that, within the mesopleural plate, the pre-alar apophysis is pushed anteriorly towards the vertical cleft. The cuticle of the mesopleural plate on the posterior side of the vertical cleft appears to be forced into the vertical cleft or under the mesopleural plate. There is also a buckling of the cuticle in the suture between the notopleurite and the mesopleural plate.

      (Soanes and Bell, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tsh(04319)8.1
      (Soanes and Bell, 2001)
      tsh8.1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)