FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\easalaE13
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General Information
Symbol
Dmel\easalaE13
Species
D. melanogaster
Name
FlyBase ID
FBal0125160
Feature type
allele
Associated gene
Dmel\eas
Associated Insertion(s)
Carried in Construct
Also Known As
alaE13
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Pascual et al., 2005)
Mutagen
Delta2-3 transposase
(Boquet et al., 2000)
Progenitor genotype
easalaP
(Boquet et al., 2000)
Cytology
Description

Excision of the P{GawB} element.

(Boquet et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  epilepsy
      CEA
      (Moore and Taylor, 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      easalaE13 mutants show no bang-sensitive phenotype, either as homozygotes or as transheterozygotes with eas2 or Df(1)4b18. Two cell/single cell MARCM clones in the mushroom body of easalaE13 flies do not branch when invading the dorsal or medial lobes in 50% of cases. In the other 50% of clones, axons branch and project into the same lobe. However, both branched and unbranched α'/α and β'/β axons are present in easalaE13 mutants with the missing lobe phenotype, indicating that axon branching is not the primary defect in these mutants. The number of MARCM clones generated in a easalaE13 background is reduced compared to the number generated in a wild-type background. easalaE13 clones, generated in a easalaE13/+ background using the MARCM technique, do not show axonal guidance defects.

      (Pascual et al., 2005)

      10.5 +/- 2.8% of mutant flies have all five mushroom body lobes in both hemispheres, 36 +/- 2.4% lack the β and β' lobes in both hemispheres and 4.5 +/- 1.1% lack the α and α' vertical lobes. The remaining flies have different combinations of mushroom body phenotype in the left and right hemisphere. Fusion of the left and right β and β' lobes is also seen. γ lobes appear to be normal.

      (Pascual and Preat, 2001)

      Homozygous adults have a strong central brain phenotype; α lobes are missing and β lobes are fused.

      (Boquet et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      easalaE13 is partially rescued by Scer\GAL4ey-OK107/easUAS.cPa

      (Pascual et al., 2005)

      easalaE13 is partially rescued by eashs.PP

      (Pascual et al., 2005)
      Comments

      The majority of flies have brains of wild-type appearance when easScer\UAS.cPa is expressed under the control of Scer\GAL4OK107 in a easalaE13 background. Expression of eashs.PP can almost completely rescue the mushroom body phenotype of easalaE13/Y flies if initiated on the first day of the third-larval stage. If expression is initiated in the late third-instar stage, rescue is partial and later induction fails to rescue the phenotype at all.

      (Pascual et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      alaE13
      (Pascual and Preat, 2001, Boquet et al., 2000)
      easalaE13
      (Moore and Taylor, 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)