FlyBase Allele Report: Dmel\Tak1[unspecified]

General Information

Symbol

Dmel\Tak1^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0126471

Feature type

allele

Associated gene

Dmel\Tak1

Associated Insertion(s)

Carried in Construct

Also Known As

dtak1

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Vidal et al., 2001)

viable

(Stronach and Perrimon, 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes have no apparent tissue polarity defects.

(Stronach and Perrimon, 2002)

Mutant flies are weakly susceptible to Gram-negative bacterial infection and resistant to Gram-positive bacterial and fungal infection.

(Vidal et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tak1[+]/Tak1^unspecified is a suppressor | partially of lethal - all die during embryonic stage phenotype of POSH^UAS.cSa, Scer\GAL4^pnr-MD237

(Zhang et al., 2010)

NOT Suppressor of

Statement

Reference

Tak1^unspecified is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, hep^CA.UAS

(Geuking et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tak1[+]/Tak1^unspecified is a suppressor of embryonic dorsal epidermis | dorsal closure stage phenotype of POSH^UAS.cSa, Scer\GAL4^pnr-MD237

(Zhang et al., 2010)

NOT Suppressor of

Statement

Reference

Tak1^unspecified is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, hep^CA.UAS

(Geuking et al., 2005)

Other

Statement

Reference

POSH^UAS.cSa, Scer\GAL4^pnr-MD237, Tak1[+]/Tak1^unspecified has adult external thorax phenotype

(Zhang et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Tak1^unspecified/+ partially suppresses the lethal dorsal open phenotype of Scer\GAL4^pnr-MD237>POSH^Scer\UAS.cSa. Escapees survive to adulthood with thorax defects.

(Zhang et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tak1^unspecified is rescued by Tak1^+t15

(Vidal et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tak1^unspecified

dtak1

(Radyuk et al., 2010, Zhang et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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