FlyBase Allele Report: Dmel\Cadps[BD]

General Information

Symbol

Dmel\Cadps^BD

Species

D. melanogaster

Name

FlyBase ID

FBal0126635

Feature type

allele

Associated gene

Dmel\Cadps

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Renden et al., 2001)

Mutagen

ethyl methanesulfonate

(Renden et al., 2001)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | recessive

(Renden et al., 2001)

abnormal neurophysiology | recessive

(Renden et al., 2001)

abnormal touch response | recessive

(Renden et al., 2001)

decreased rate of movement | recessive

(Renden et al., 2001)

lethal (with Df(4)sc^H)

(Renden et al., 2001)

lethal | recessive

(Renden et al., 2001)

Phenotype Manifest In

neuromuscular junction

(Renden et al., 2001)

Detailed Description

Statement

Reference

Mutants die at the late embryo/early first larval instar; a small minority of mutant larvae (less than 10%) hatch from the egg case but they all die during early to mid 1st instar. No gross morphological abnormalities are seen; the body plan appears fully differentiated and there are no defects in epidermal segmentation or patterning. The gut, tracheal system, musculature and nervous system appear fully differentiated with no detectable morphological abnormalities. Mutant neuromuscular junctions appear well differentiated with normally sized boutons and terminal size and number of boutons appears normal. Mutants show severe sluggishness, reduced endogenous locomotory movements and a lack of response to nose-touch. At a basal stimulation level, mean EJC amplitude at the embryonic neuromuscular junction (NMJ) is reduced by about 50% compared to controls.

(Renden et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Cadps^BD has lethal | recessive phenotype, suppressible by Rnor\Cadps^UAS.cRa/Scer\GAL4^e22c

(Renden et al., 2001)

Other

Statement

Reference

Cadps^BD, Rnor\Cadps^UAS.cRa, Scer\GAL4^e22c has viable phenotype

(Renden et al., 2001)

Cadps^BD, Rnor\Cadps^UAS.cRa, Scer\GAL4^e22c has wild-type phenotype

(Renden et al., 2001)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Caps^BD flies expressing Rnor\CAPS^Scer\UAS.cRa under the control of Scer\GAL4^e22c have no detectable morphological or behavioural defects.

(Renden et al., 2001)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: mutation that is lethal over Ts(1Lt;4Lt)sc^H.

(Renden et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cadps^BD

Caps^BD

dCAPS^BD

(Renden et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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