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General Information
Symbol
Dmel\me31BΔ2
Species
D. melanogaster
Name
FlyBase ID
FBal0127208
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{lacW} element resulting in a deletion starting from the original insertion point of the element and extending into the me31B coding region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes die during the 2nd to 3rd larval instar without any discernible morphological defects. Homozygous egg chambers in female germ-line clones do not complete oogenesis. Most of the egg chambers degenerate during mid-oogenesis, such that the cell membranes of germline cells are collapsed and ring canals and nurse cell nuclei are concentrated to form large aggregates within egg chambers. Nurse cell nuclei in these egg chambers are then fragmented into small pieces. Occasionally, egg chambers which have progressed to stage 10 are seen. In these egg chambers, the oocyte does not grow normally the and the nurse cell nuclei are displaced posteriorly relative to the anterior border of columnar follicle cells (which normally surround the oocyte at stage 10). The egg chambers are morphologically normal until stage 4-5 and the oocyte fails to grow normally from stage 6 onwards, at which stage the egg chambers begin to degenerate.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Fmr13, me31B[+]/me31BΔ2 has abnormal learning | dominant phenotype, suppressible by Fmr1+t14

Atx2X1, me31B[+]/me31BΔ2 has abnormal learning | dominant phenotype, suppressible by Atx2+t10.4

Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Atx2X1, me31B[+]/me31BΔ2 has antennal lobe glomerulus V phenotype, suppressible by Atx2+t10.4

Other
Additional Comments
Genetic Interactions
Statement
Reference

Fmr1Δ50M, me31BΔ2 double heterozygotes exhibit a complete block of the long-term habituation (LTH) normally seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Fmr1+t14. Short term habituation following one hour exposure to EB appears normal.

me31BΔ2, Atx2X1 double heterozygotes exhibit a complete block of the long-term habituation (LTH) seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Atx2+t10.4. Short term habituation following 1 hour exposure to EB appears normal. LTH-associated structural plasticity is also blocked: although the V and DM5 glomeruli of Atx2X1/+ flies show the expected growth following 4d of CO[[2]] or EB exposure, respectively, both the EB-evoked increase in DM5 volume and the CO[[2]]-induced increase in V are abolished in me31BΔ2/+; Atx2X1/+ double heterozygotes. These defects in structural plasticity are restored by Atx2+t10.4.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)