FlyBase Allele Report: Dmel\bsk[UAS.cAYa]

General Information

Symbol

Dmel\bsk^UAS.cAYa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Adachi-Yamada

FlyBase ID

FBal0128031

Feature type

allele

Associated gene

Dmel\bsk

Associated Insertion(s)

Carried in Construct

P{UAS-bsk.A-Y}

Also Known As

UAS-bsk, UAS-bsk^A-Y

Key Links

Transgenic product class

cDNA

(Adachi-Yamada, 2001.12.13)

wild_type

(Adachi-Yamada, 2001.12.13)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Adachi-Yamada, 2001.12.13)

wild_type

(Adachi-Yamada, 2001.12.13)

Mutagen

in vitro construct

(Adachi-Yamada, 2001.12.13)

Progenitor genotype

Carried in construct

P{UAS-bsk.A-Y}

Cytology

Description

Expression of bsk cDNA is governed by UAS regulatory sequences.

(Adachi-Yamada, 2001.12.13)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

bsk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell growth rate, with Scer\GAL4^sd-SG29.1

(Fernández et al., 2014)

increased cell death, with Scer\GAL4^sd-SG29.1

(Fernández et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of bsk^{Scer\UAS.cAYa} under the control of Scer\GAL4^sd-SG29.1 increases apoptosis and reduces tissue growth.

(Fernández et al., 2014)

Expression of bsk^{Scer\UAS.cAYa} under the control of Scer\GAL4^ple.PF or Scer\GAL4^elav.PU leads to an increase in survival duration by about 5-7 days when exposed to 0.5ppm 1-octen-3-ol.

(Inamdar et al., 2014)

Larval ddaE neurons expressing bsk^UAS.cAYa under the control of Scer\GAL4²²¹ (and Dicer-2, for a more efficient RNAi) do not show significant changes in the number of growing microtubules within dendrites 8h after axotomy, or in the proportion of dendrites persisting after consecutive axotomy and dendrite severance (i.e. axotomy-8h-dendrite severance-18h), as compared to similarly injured control neurons.

(Chen et al., 2012)

Expression of bsk^{Scer\UAS.cAYa} under the control of Scer\GAL4^pnr-MD237 has no affect on the adult notum.

(Yoshioka et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

bsk^UAS.cAYa, Scer\GAL4^pnr-MD237 is a suppressor of visible phenotype of Dref^RNAi.UAS.cUa, Scer\GAL4^pnr-MD237

(Yoshioka et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

bsk^UAS.cAYa, Scer\GAL4^pnr-MD237 is a suppressor of adult thorax phenotype of Dref^RNAi.UAS.cUa, Scer\GAL4^pnr-MD237

(Yoshioka et al., 2012)

bsk^UAS.cAYa, Scer\GAL4^pnr-MD237 is a suppressor of mesonotum phenotype of Nf-YA^{RNAi.231-399.UAS.WIZ}, Scer\GAL4^pnr-MD237

(Yoshioka et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of cpa^{Scer\UAS.N.T:Ivir\HA1} and cpb^Scer\UAS.cWa significantly restores tissue growth and suppresses apoptosis in flies expressing bsk^{Scer\UAS.cAYa} under the control of Scer\GAL4^sd-SG29.1.

(Fernández et al., 2014)

The split thorax phenotype caused by expression of Dref^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^pnr-MD237 is suppressed by co-expression of bsk^{Scer\UAS.cAYa}.

(Yoshioka et al., 2012)

The cleft notum phenotype caused by expression of Nf-YA^{dsRNA.231-399.Scer\UAS.WIZ} under the control of Scer\GAL4^pnr-MD237 is suppressed by co-expression of bsk^{Scer\UAS.cAYa}.

(Yoshioka et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^Tab2-201Y/bsk^UAS.cAYa rescues bsk^LL02244

(Bornstein et al., 2015)

Comments

Expressing bsk^{Scer\UAS.cAYa} in bsk^LL02244/bsk^LL02244 clones (with Scer\GAL4^Tab2-201Y) rescues axon-pruning defects.