FlyBase Allele Report: Dmel\Nf1[UAS.cdNa]

General Information

Symbol

Dmel\Nf1^UAS.cdNa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of de Nooij

FlyBase ID

FBal0128150

Feature type

allele

Associated gene

Dmel\Nf1

Associated Insertion(s)

Carried in Construct

P{UAS-Nf1.dN}

Also Known As

UAS-Nf1

Key Links

Transgenic product class

wild_type

(Williams et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Williams et al., 2001)

Mutagen

in vitro construct

(Williams et al., 2001, Williams et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-Nf1.dN}

Cytology

Description

UAS regulatory sequences drive expression of Nf1.

(Williams et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Nf1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Nf1^{Scer\UAS.cdNa} driven by Scer\GAL4^nSyb.PS does not significantly increase total sleep compared to flies with Nf1^{Scer\UAS.cdNa}/+ controls.

(Bai and Sehgal, 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav.PU/Nf1^UAS.cdNa rescues Nf1^E1/Nf1^E2

(Durkin et al., 2023)

Nf1^UAS.cdNa/Scer\GAL4^ChAT.7.4 rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^nSyb.PS/Nf1^UAS.cdNa rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^nSyb.PS/Nf1^UAS.cdNa rescues Nf1^P2/Nf1^P1

(Bai and Sehgal, 2015)

Scer\GAL4^elav-C155/Nf1^UAS.cdNa rescues Nf1^P1

(Williams et al., 2001)

Partially rescues

Scer\GAL4^c453/Nf1^UAS.cdNa partially rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^c309/Nf1^UAS.cdNa partially rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^NP2024/Nf1^UAS.cdNa partially rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^53b/Nf1^UAS.cdNa partially rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^MJ63/Nf1^UAS.cdNa partially rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^Kurs58/Nf1^UAS.cdNa partially rescues Nf1^P2/Nf1^P1

(Bai et al., 2018)

Fails to rescue

Nf1^UAS.cdNa/Scer\GAL4^Ddc.PL fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^Tdc2.PC/Nf1^UAS.cdNa fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Nf1^UAS.cdNa/Scer\GAL4¹⁴⁷¹ fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^Tab2-201Y/Nf1^UAS.cdNa fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Nf1^UAS.cdNa/Scer\GAL4^c739 fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^dimm-929/Nf1^UAS.cdNa fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^Clk.1.5/Nf1^UAS.cdNa fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^0911-G4/Nf1^UAS.cdNa fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Scer\GAL4^121Y/Nf1^UAS.cdNa fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Nf1^UAS.cdNa/Scer\GAL4^P2.4.Pdf fails to rescue Nf1^P2/Nf1^P1

(Bai et al., 2018)

Nf1^UAS.cdNa/Scer\GAL4^P2.4.Pdf fails to rescue Nf1^P1

(Williams et al., 2001)

Scer\GAL4^tim.PE/Nf1^UAS.cdNa fails to rescue Nf1^P1

(Williams et al., 2001)

Comments

Expression of Nf1^{Scer\UAS.cdNa} driven by Scer\GAL4^nSyb.PS rescues the decreases in total sleep seen in Nf1^P1/Nf1^P2 male and female flies, even significantly increasing total sleep beyond wild type amounts.

(Bai and Sehgal, 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

J. de Nooij

(Williams et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Nf1^{Scer\UAS.cdNa}

Nf1^UAS.cdNa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of de Nooij

(Williams et al., 2001)

Secondary FlyBase IDs

References (5)

Report Sections

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