FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NctJ1
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General Information
Symbol
Dmel\NctJ1
Species
D. melanogaster
Name
FlyBase ID
FBal0129202
Feature type
allele
Associated gene
Dmel\Nct
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Hu et al., 2002)
Mutagen
ethyl methanesulfonate
(Hu et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: A197V.

(Hu et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,852,415..24,852,415 [+]
Nucleotide change:

C24852415T

Amino acid change:

A197V | nct-PA; A197V | nct-PC; A197V | nct-PD; A197V | nct-PE

Reported amino acid change:

A197V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Hu et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      larva

      (Hu et al., 2002)

      sensory mother cell & dorsal mesothoracic disc

      (Hu et al., 2002)
      Detailed Description
      Statement
      Reference

      Expression of nctScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PU partially rescues the lethality of nctJ1.

      (Stempfle et al., 2010)

      Mutant larvae secrete a pupal case but do not form any adult structures and instead collapse into an oily mass within the pupal case. Clusters of sensillum precursors in the wing disc are expanded.

      (Hu et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      NctJ1 is rescued by NctUAS.Tag:MYC/Scer\GAL4da.G32

      (Stempfle et al., 2010)
      Partially rescued by

      NctJ1 is partially rescued by NctUAS.Tag:MYC/Scer\GAL4hs.PU

      (Stempfle et al., 2010)
      Comments

      Expression of nctScer\UAS.T:Hsap\MYC under the control of Scer\GAL4da.G32 rescues the lethality of nctJ1.

      Expression of nctScer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.PU partially rescues the lethality of nctJ1.

      (Stempfle et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      NctJ1
      NicJ1
      (Hu et al., 2002)
      nctJ1
      (Guo et al., 2003)
      nctJ1
      (Stempfle et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)