FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bonS043420
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General Information
Symbol
Dmel\bonS043420
Species
D. melanogaster
Name
FlyBase ID
FBal0129876
Feature type
allele
Associated gene
Dmel\bon
Associated Insertion(s)
P{lacW}bonS043420
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{lacW}bonS043420
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males die as first instar larvae while 86% of homozygous females eclose (all homozygous females survive at least to the second larval instar stage). Most homozygous females appear morphologically normal and fertile, although a small number have a rough eye phenotype. The presence of a Y chromosome in bonS043420/bonS043420 females (XXY animals) results in 100% lethality, while the absence of a Y chromosome in bonS043420/bonS043420 males (XO animals) rescues the lethality seen in XY bonS043420/bonS043420 males.

      (Beckstead et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      bonS043420 has lethal | recessive | male limited | first instar larval stage phenotype, non-suppressible by Sxlf1

      (Beckstead et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lethality of bonS043420 homozygous males is not rescued if they are also carrying Sxlf1; almost no escapers are seen. XX tra21/tra2B ; bonS043420/bonS043420 animals, that are genetically female (XX) but phenotypically male are viable.

      (Beckstead et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      bonS043420 fails to complement bonS024108, bon21B and Df(3R)H81 with respect to male lethality while it only partially fails to complement with respect to female lethality.

      (Beckstead et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      0434/20
      (Deak et al., 1997)
      bon434
      (Beckstead et al., 2005)
      bonS043420
      l(3)S043420S043420
      Name Synonyms
      Secondary FlyBase IDs
        References (2)