FB2026_02 , released June 18, 2026
Allele: Dmel\fwsKG02853
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General Information
Symbol
Dmel\fwsKG02853
Species
D. melanogaster
Name
FlyBase ID
FBal0130319
Feature type
allele
Associated gene
Dmel\fws
Associated Insertion(s)
P{SUPor-P}fwsKG02853
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Fári et al., 2016)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}fwsKG02853
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A majority of fwsKG02853/fwsKG02853 and fwsKG02853 hemizygous males are sterile. Sterile fwsKG02853/fwsKG02853 males show lack of mature sperm in the seminal vesicles. Meiotic cytokinesis and post-meiotic cyst elongation in fwsKG02853/fwsKG02853 mutant males are normal, there is some scattering of nuclei and investment cones in mutant cysts, the majority of elongated spermatids do not form acrosomes, and there are defects in the perinuclear acroblast, as compared to controls.

      (Fári et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      fwsKG02853 is rescued by fwsGFP

      (Fári et al., 2016)
      Comments

      Expression of fwsT:Avic\GFP rescues the sterility of fwsKG02853 mutant males.

      (Fári et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the insertion completely reverts the male sterile phenotype.

      (Fári et al., 2016)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fwsKG02853
      (Fári et al., 2016)
      fwsP
      (Fári et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)