FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RpLP1beo
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General Information
Symbol
Dmel\RpLP1beo
Species
D. melanogaster
Name
FlyBase ID
FBal0130781
Feature type
allele
Associated gene
Dmel\RpLP1
Associated Insertion(s)
P{lacW}RpLP1beo
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Fauvarque et al., 2001)
Progenitor genotype
Associated Insertion(s)
P{lacW}RpLP1beo
Cytology
Description

P{lacW} insertion in the 5' transcribed region of RpLP1, disrupting the coding region.

(Fauvarque et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intrinsic cardiomyopathy
      CEA
      (Casad et al., 2011)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous RpLP1beo mutant females exhibit a dilated cardiomyopathy phenotype, including an increased end-systolic dimension (EDD) and a decreased fractional shortening (FS) compared to controls. Bristles appear short and thin compared to wild type (Minute phenotype) .

      (Casad et al., 2011)

      Heterozygotes show a characteristic Minute bristle phenotype and developmental delay (of 5 to 10 hours).

      (Fauvarque et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      RpLP1[+]/RpLP1beo is an enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)

      RpLP1[+]/RpLP1beo is an enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      RpLP1[+]/RpLP1beo is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)

      RpLP1[+]/RpLP1beo is an enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Suppressor of
      Statement
      Reference

      RpLP1[+]/RpLP1beo is a suppressor of metathoracic leg phenotype of ph-p410

      (Fauvarque et al., 2001)

      RpLP1[+]/RpLP1beo is a suppressor of sex comb | ectopic phenotype of ph-p410

      (Fauvarque et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes.

      (Fauvarque et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: a suppressor of the meta- to pro-thoracic leg transformation seen in ph-p410/Y flies.

      (Fauvarque et al., 2001)
      Comments
      Comments

      Excision of the P{lacW} element reverts the phenotype.

      (Fauvarque et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      RpLP1beo
      (Feuillette et al., 2020, Casad et al., 2011)
      RpP2beo
      beo
      (Fauvarque et al., 2001)
      Name Synonyms
      belenos
      (Fauvarque et al., 2001)
      Secondary FlyBase IDs
        References (5)