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General Information
Symbol
Dmel\Dif2
Species
D. melanogaster
Name
FlyBase ID
FBal0131264
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C17418260T

    Reported nucleotide change:

    C1296T

    Amino acid change:

    S245F | Dif-PA; S245F | Dif-PB; S245F | Dif-PC; S245F | Dif-PD

    Reported amino acid change:

    S245F

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: S245F.

    Nucleotide substitution: C1296T.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Dif2/Df(2L)J4 and Dif1/Dif2 larvae do not show R2-R5 photoreceptor axon targeting defects in the developing visual system.

    Mutant flies show reduced survival compared to wild-type controls after infection with S. pyogenes or with Cryptococcus neoformans.

    Dif2 flies are highly susceptible to infection by Gram-positive bacteria (E.faecalis previously known as 'Streptococcus faecalis').

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    Statement
    Reference
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    In lwr4-3/lwr5; Dif2/Df(2L)J4 double mutants the number of lamellocytes are the same as in wild-type larvae, while the number of plasmatocytes is reduced compared to lwr4-3/lwr5 single mutants, but remain higher than in wild type.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    References (13)