FlyBase Allele Report: Dmel\beag[EP3260]

General Information

Symbol

Dmel\beag^EP3260

Species

D. melanogaster

Name

FlyBase ID

FBal0131563

Feature type

allele

Associated gene

Dmel\beag

Associated Insertion(s)

P{EP}beag^EP3260

Carried in Construct

Also Known As

EP3260

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}beag^EP3260

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:9,064,864..9,064,864 [+]

(Beck et al., 2012, Schulz et al., 2004, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage (with beag¹)

(Beck et al., 2012)

abnormal neuroanatomy | third instar larval stage (with Df(3R)Exel6151)

(Beck et al., 2012)

abnormal neurophysiology | third instar larval stage (with beag¹)

(Beck et al., 2012)

Phenotype Manifest In

germline cell | male, with Scer\GAL4^ptc-559.1

(Schulz et al., 2004)

NMJ bouton | third instar larval stage (with beag¹)

(Beck et al., 2012)

NMJ bouton | third instar larval stage (with Df(3R)Exel6151)

(Beck et al., 2012)

Detailed Description

Statement

Reference

beag¹/beag^EP3260 larvae have decreased numbers of NMJ synaptic boutons compared to wild type.

Df(3R)Exel6151/beag^EP3260 larvae have decreased numbers of NMJ synaptic boutons compared to wild type.

beag¹/beag^EP3260 animals have a 47% decrease in EJP amplitude at the larval NMJ compared with wild type. mEJP amplitude and frequency are unchanged, leading to a 34% decrease in quantal content compared with wild type.

(Beck et al., 2012)

Expression of CG18005^EP3260 under the control of Scer\GAL4^ptc-559.1 (the animals are initially raised at 18^oC and then shifted to 29^oC after 10 days) results in a reduced number of early germ cells (stem cells, gonialblasts and spermatogonia) in the testis.

(Schulz et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Df(3R)Exel6151/beag^EP3260 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Smu1^f03090/Df(3R)Exel6182

(Beck et al., 2012)

NOT Enhancer of

Statement

Reference

Df(3R)Exel6151/beag^EP3260 is a non-enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Smu1^f03090/Df(3R)Exel6182

(Beck et al., 2012)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Df(3R)Exel6151/beag^EP3260 has NMJ bouton | third instar larval stage phenotype, non-enhanceable by Smu1^f03090/Df(3R)Exel6182

(Beck et al., 2012)

NOT Enhancer of

Statement

Reference

Df(3R)Exel6151/beag^EP3260 is a non-enhancer of NMJ bouton | third instar larval stage phenotype of Smu1^f03090/Df(3R)Exel6182

(Beck et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The decrease in synaptic bouton number in beag^EP3260/Df(3R)Exel6151, Smu1^f03090/Df(3R)Exel6182 double mutants is not significantly different from that observed in either single hemizygous mutant.

(Beck et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

beag¹/beag^EP3260 is rescued by Scer\GAL4^RapGAP1-OK6/beag^UAS.cBa

(Beck et al., 2012)

Comments

Expression of beag^Scer\UAS.cBa using Scer\GAL4^Rapgap1-OK6 fully rescues the reduction in EJP amplitude and quantal content in beag¹/beag^EP3260 mutants.

(Beck et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: ird1^unspecified.

(Wu et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG18005^EP3260

EP3260

(Wu et al., 2007)

beag^EP3260

(Beck et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close