FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\14-3-3ζLII.2.hs
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General Information
Symbol
Dmel\14-3-3ζLII.2.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0134435
Feature type
allele
Associated gene
Dmel\14-3-3ζ
Associated Insertion(s)
Carried in Construct
P{hs-14-3-3ζ.LII.2}
Key Links
Transgenic product class
cDNA
(Philip et al., 2001)
wild_type
(Philip et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Philip et al., 2001)
wild_type
(Philip et al., 2001)
Mutagen
in vitro construct
(Philip et al., 2001)
Progenitor genotype
Carried in construct
P{hs-14-3-3ζ.LII.2}
Cytology
Description

Expression of a 14-3-3ζ cDNA exons 1-6',7 is driven by a heat shock promoter.

(Philip et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
14-3-3ζ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      14-3-3ζLII.2.hs is a non-suppressor of visible phenotype of 14-3-3εex4

      (Acevedo et al., 2007)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      14-3-3ζLII.2.hs is a non-suppressor of anterior crossvein phenotype of 14-3-3εex4

      (Acevedo et al., 2007)

      14-3-3ζLII.2.hs is a non-suppressor of posterior crossvein phenotype of 14-3-3εex4

      (Acevedo et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      14-3-3ζLII.2.hs rescues 14-3-3ζ2.3

      (Philip et al., 2001)

      14-3-3ζLII.2.hs rescues 14-3-3ζP1375

      (Philip et al., 2001)

      14-3-3ζLII.2.hs rescues 14-3-3ζX1

      (Philip et al., 2001)
      Fails to rescue

      14-3-3ζLII.2.hs fails to rescue 14-3-3ζP1188

      (Philip et al., 2001)

      14-3-3ζLII.2.hs fails to rescue 14-3-3ζ07103

      (Philip et al., 2001)
      Comments

      Induction with two 30 min heat shocks daily through embryonic, larval and pupal stages rescues the lethal phenotype of 14-3-3ζP1375. A single heat shock daily can also rescue to adulthood. Shows heat-shock specific rescue of the learning and memory defects of 14-3-3ζX1 and 14-3-3ζ2.3. Flies rescued from lethality by 14-3-3ζLI.15.hs and 14-3-3ζLII.2.hs show a 25-30% decrement in olfactory learning, comparable to that of (rescued) 14-3-3ζ2.3. The restoration of learning by the transgenes decays back to mutant levels 60-70 hr later.

      (Philip et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      14-3-3ζLII.2.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (2)