FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pygo10
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General Information
Symbol
Dmel\pygo10
Species
D. melanogaster
Name
FlyBase ID
FBal0138164
Feature type
allele
Associated gene
Dmel\pygo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Parker et al., 2002)
Progenitor genotype
pygoEP1076
(Parker et al., 2002)
Cytology
Description

Imprecise excision has caused the 3' half of the P{EP}pygoEP1076 insertion to be removed along with the splice acceptor site in the 5' UTR intron of the pygo gene, and the first 295 residues of the ORF.

(Parker et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
3R:31,578,746..31,579,900 [-]
Comment:

Deletion associated with the imprecise excision of P{EP}pygoEP1076. Half of the P element remains.

(Parker et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Apoptosis occurring at the edge of the developing eye 42 hours after puparium formation is eliminated in somatic clones homozygous for pygo10. Ectopic photoreceptor clusters occur in these clones at this stage when they fall at the edge of the developing eye.

      (Lin et al., 2004)

      Ectopic photoreceptors are produced in homozygous clones at the edge of the eye.

      (Lin et al., 2003)

      About half of embryos that are homozygous pygo10 for the maternal contribution of pygo and are also zygotically pygo10 have no naked cuticle is formed and a denticle lawn phenotype. Those mutant embryos that are have a wild-type paternal copy of pygo have a reduction in the number of denticle belts with some denticle fusions. Homozygous mutant imaginal discs are severely reduced in size. When homozygous mutant clones are made in the wing, notches are often seen, a loss of the wing margin and the associated bristles is seen.

      (Parker et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      pygo10 has imaginal disc phenotype, non-enhanceable by Axnunspecified

      (Parker et al., 2002)
      NOT suppressed by
      Statement
      Reference

      pygo10 has imaginal disc phenotype, non-suppressible by Axnunspecified

      (Parker et al., 2002)
      Suppressor of
      Statement
      Reference

      pygo10 is a suppressor of photoreceptor neuron | somatic clone phenotype of Axnunspecified

      (Parker et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of pygo10 completely suppresses the photoreceptor cell phenotype seen in Axnunspecified mutants. The pygo10 phenotype remains unaffected.

      (Parker et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      pygo10 is partially rescued by pygoUAS.cPa/Scer\GAL4da.G32

      (Parker et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pygo10
      (Yang et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)