FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mysM2
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General Information
Symbol
Dmel\mysM2
Species
D. melanogaster
Name
FlyBase ID
FBal0138198
Feature type
allele
Associated gene
Dmel\mys
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Jannuzi et al., 2002)
Mutagen
ethyl methanesulfonate
(Jannuzi et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q66term.

(Jannuzi et al., 2002)

Nucleotide substitution: C196T.

(Jannuzi et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:8,064,153..8,064,153 [+]
Nucleotide change:

C8064153T

Reported nucleotide change:

C196T

Amino acid change:

Q66term | mys-PA; Q66term | mys-PB; Q66term | mys-PC; Q66term | mys-PD

Reported amino acid change:

Q66term

(Jannuzi et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult-generated mysM2 homozygous mutant intestinal stem cell clones have reduced maintenance 7 days and 14 days after clone induction compared to control clones; remaining clones contain fewer cells by day 14 and many only contain differentiated cells; enteroendocrine cell/enterocyte ratio is unaffected and intestinal stem cells show no obvious signs of apoptosis.

      (Lin et al., 2013)

      Loss of mys in mysM2 mutant clones results in scars forming in the underlying basement membrane, indicating that integrins are involved in the capture by tissues of Collagen IV from the contacting haemolymph.

      (Pastor-Pareja and Xu, 2011)

      mysM2 dorsal branch terminal cell clones in third instar larvae show substantial branch pruning and multiple convoluted lumens coursing through the remaining terminal branches.

      (Levi et al., 2006)

      Homozygous somatic clones in the wing result in wing blisters. Mutant embryos show dorsal herniation. mysb7/mysM2 animals show 92% viability.

      (Jannuzi et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Adult posterior midguts from mysM2/+; Itgbn1/Itgbn1 have a similar proportion of intestinal stem cells to Itgbn1 heterozygotes and homozygotes.

      (Lin et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mysM2 is rescued by Scer\GAL4Act.PU/mysUAS.cLa

      (Lin et al., 2013)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mysM2
      (Hartman et al., 2015, Lin et al., 2013, Pastor-Pareja and Xu, 2011, Levi et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)