FlyBase Allele Report: Dmel\sw[Dic-2]

General Information

Symbol

Dmel\sw^Dic-2

Species

D. melanogaster

Name

FlyBase ID

FBal0140914

Feature type

allele

Associated gene

Dmel\sw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Boylan and Hays, 2002)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Boylan and Hays, 2002)

paralytic | larval stage

(Boylan and Hays, 2002)

some die during larval stage | recessive

(Boylan and Hays, 2002)

visible (with sw¹)

(Boylan and Hays, 2002)

Phenotype Manifest In

wing (with sw¹)

(Boylan and Hays, 2002)

Detailed Description

Statement

Reference

Hemizygotes survive to the third larval instar. The larvae have a crawling defect which results in complete paralysis with the heads of the larvae poking up out of the food. sw^Dic-2/sw¹ flies have a mild wing phenotype at 28^oC.

(Boylan and Hays, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sw^Dic-2/sw[+] is an enhancer of visible | dominant phenotype of DCTN1-p150^Gl-1

(Boylan and Hays, 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

sw^Dic-2/sw[+] is an enhancer of eye photoreceptor cell & nucleus phenotype of DCTN1-p150^Gl-1

(Whited et al., 2004)

sw^Dic-2/sw[+] is an enhancer of ommatidium phenotype of DCTN1-p150^Gl-1

(Boylan and Hays, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The area of the retina of late third instar Gl¹/+ larvae devoid of nuclei is significantly increased by sw^Dic-2/+. This is not due to cell death, but instead due increased migration of nuclei into the optic stalk.

(Whited et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sw^Dic-1

(Boylan and Hays, 2002)

sw^Dic-3

(Boylan and Hays, 2002)

sw¹

(Boylan and Hays, 2002)