FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CamB34Q.UAS
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General Information
Symbol
Dmel\CamB34Q.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0141861
Feature type
allele
Associated gene
Dmel\Cam
Associated Insertion(s)
Carried in Construct
P{UAS-Cam.B34Q}
Key Links
Transgenic product class
missense_variant
(Wang et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wang et al., 2002)
Mutagen
in vitro construct
(Wang et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Cam.B34Q}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of Cam in which the two C-terminal Ca[2+] binding sites have been inactivated by E to Q changes.

(Wang et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cam
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CamB34Q.Scer\UAS under the control of Scer\GAL4how-24B in Cam7/+ animals (which are normally phenotypically wild type) results in less than half the animals pupariating and some pupae have body wrinkles similar to that seen in Cam7 hemizygotes. Expression of CamB34Q.Scer\UAS under the control of Scer\GAL4how-24B in a Cam+ background results in significant death before pupariation and the formation of abnormal pupal cases in some survivors. Expression of both CamB12Q.Scer\UAS and CamB34Q.Scer\UAS under the control of Scer\GAL4how-24B in Cam7/Camn339 animals results in 100% larval lethality.

      (Wang et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      CamB34Q.UAS/Scer\GAL4elav.PLu fails to rescue Camn339

      (Wang et al., 2003)

      CamB34Q.UAS/Scer\GAL4how-24B fails to rescue Cam7/Camn339

      (Wang et al., 2002)
      Comments

      (with CamB12Q.Scer\UAS) Fails to rescue: Camn339 { Scer\GAL4elav.PLu } The spontaneous backward movement seen in homozygous Camn339 larvae is not rescued by expression of CamB34Q.Scer\UAS under the control of Scer\GAL4elav.PLu. The spontaneous backward movement seen in homozygous Camn339 larvae is not rescued by co-expression of CamB12Q.Scer\UAS and CamB34Q.Scer\UAS under the control of Scer\GAL4elav.PLu.

      (Wang et al., 2003)

      Expression of CamB34Q.Scer\UAS under the control of Scer\GAL4how-24B fails to rescue the Cam7/Camn339 phenotype and these animals have more extreme muscle problems than Cam7/Camn339 animals; Cam7/Camn339 larvae expressing CamB34Q.Scer\UAS under the control of Scer\GAL4how-24B are extremely contracted and have difficulty producing the cyclic waves of contraction/expansion for locomotion.

      (Wang et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CamB34Q.Scer\UAS
      CamB34Q.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)