FlyBase Allele Report: Dmel\phol[81A]

General Information

Symbol

Dmel\phol^81A

Species

D. melanogaster

Name

FlyBase ID

FBal0143284

Feature type

allele

Associated gene

Dmel\phol

Associated Insertion(s)

P{?EP}phol^81A

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Brown et al., 2003)

Mutagen

Delta2-3 transposase

(Brown et al., 2003)

Progenitor genotype

P{EP}phol^EP559

(Brown et al., 2003)

Associated Insertion(s)

P{?EP}phol^81A

Cytology

Description

Imprecise excision of the P{EP} element, resulting in deletion of part of the element along with the entire phol coding region.

(Brown et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Brown et al., 2003)

lethal | embryonic stage | germline clone | maternal effect | recessive

(Brown et al., 2003)

lethal | embryonic stage | maternal effect | recessive

(Brown et al., 2003)

male fertile

(Brown et al., 2003)

viable

(Brown et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes look phenotypically normal and have no obvious homeotic phenotypes. Homozygous females or females containing homozygous germline clones lay eggs which look normal and are fertilised, but fail to develop.

(Brown et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

pho¹, phol^81A has lethal | larval stage phenotype

(Brown et al., 2003)

Phenotype Manifest In

Other

Statement

Reference

pho¹, phol^81A has imaginal disc phenotype

(Brown et al., 2003)

pho¹, phol^81A has larval brain phenotype

(Brown et al., 2003)

pho¹, phol^81A has polytene chromosome phenotype

(Brown et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

phol^81A ; pho¹ double mutants die as third instar larvae and fail to pupate. The brain is smaller than normal, the disks are misshapen and smaller than normal and the salivary gland polytene chromosomes are enlarged in double mutant third instar larvae.

(Brown et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24164

y¹ w^*; phol^81A/TM3, Ser¹ y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

phol^81A

(Elizarev et al., 2021, Tian and Smith-Bolton, 2021, Vaziri et al., 2020, Domsch et al., 2019, Harris et al., 2016, Fujioka et al., 2008, Klymenko et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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