FlyBase Allele Report: Dmel\dan[ems3]

General Information

Symbol

Dmel\dan^ems3

Species

D. melanogaster

Name

FlyBase ID

FBal0144382

Feature type

allele

Associated gene

Dmel\dan

Associated Insertion(s)

P{EPg}EPgJ3-220

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Emerald et al., 2003)

Mutagen

ethyl methanesulfonate

(Emerald et al., 2003)

P-element activity

(Emerald et al., 2003)

Progenitor genotype

dan^EPgJ3-220

(Emerald et al., 2003)

Associated Insertion(s)

P{EPg}EPgJ3-220

Cytology

Description

The P{EPg}EPgJ3-220 progenitor insertion is still present on the chromosome.

(Emerald et al., 2003)

Amino acid replacement: E45K.

(Emerald et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{EPg}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:25,190,071..25,190,071 [+]

Nucleotide change:

G25190071A

Amino acid change:

E45K | dan-PA; E45K | dan-PB; E45K | dan-PC

Reported amino acid change:

E45K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Emerald et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic | adult stage | somatic clone - Minute background

(Hoang et al., 2010)

viable

(Emerald et al., 2003)

visible

(Emerald et al., 2003)

visible, with Scer\GAL4^Dll-md23

(Emerald et al., 2003)

visible | adult stage | somatic clone - Minute background

(Hoang et al., 2010)

Phenotype Manifest In

antenna

(Emerald et al., 2003)

antenna | somatic clone - Minute background

(Hoang et al., 2010)

eye | somatic clone - Minute background

(Hoang et al., 2010)

third segment of antenna

(Emerald et al., 2003)

unguis (with dan^EPgJ3-220), with Scer\GAL4^Dll-md23

(Emerald et al., 2003)

Detailed Description

Statement

Reference

dan^ems3 heterozygotes do not exhibit any size alterations or roughness in eyes when compared to control adults.

Mosaic individuals with dan^ems3 clones (in Minute background) comprising most of the eye-antennal derived structures in the adult head exhibit defects that indicate mild antenna-to-leg transformation of the distal antenna and slightly rough eyes with normal number of ommatidia when compared to control adults.

(Hoang et al., 2010)

dan^ems3 flies in which dan is overexpressed from the P{EPg}dan^EPgJ3-220 insertion using Scer\GAL4^sd-SG29.1 have normal wings. dan^ems3 flies in which dan is overexpressed from the P{EPg}dan^EPgJ3-220 insertion using Scer\GAL4^Dll-md23 show loss of claws, but not transformation to arista, in the leg. Homozygous dan^ems3 flies have mild defects in the antenna, including an occasional ectopic bristle in the third antennal segment.

(Emerald et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dan^ems3, danr^ex35 has homeotic | adult stage | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3, danr^ex35 has visible | adult stage | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3, danr^ex35 has abnormal neuroanatomy | adult stage | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3 has homeotic | adult stage | somatic clone - Minute background phenotype, enhanceable by danr^ex35/danr^ex35/CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3 has visible | adult stage | somatic clone - Minute background phenotype, enhanceable by danr^ex35/danr^ex35/CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3 has homeotic | adult stage | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3 has visible | adult stage | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

NOT Enhanced by

Statement

Reference

dan^ems3 has visible | adult stage | somatic clone - Minute background phenotype, non-enhanceable by danr^ex35/danr^ex35

(Hoang et al., 2010)

dan^ems3 has homeotic | adult stage | somatic clone - Minute background phenotype, non-enhanceable by danr^ex35/danr^ex35

(Hoang et al., 2010)

Suppressed by

Statement

Reference

CtBP^87De-10, dan^ems3 has abnormal size | adult stage | somatic clone - Minute background phenotype, suppressible | partially by danr^ex35/danr^ex35

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3 has visible | adult stage | somatic clone - Minute background phenotype, suppressible | partially by danr^ex35/danr^ex35

(Hoang et al., 2010)

NOT suppressed by

Statement

Reference

dan^ems3 has homeotic | adult stage | somatic clone - Minute background phenotype, non-suppressible by danr^ex35/danr^ex35

(Hoang et al., 2010)

dan^ems3 has visible | adult stage | somatic clone - Minute background phenotype, non-suppressible by danr^ex35/danr^ex35

(Hoang et al., 2010)

Enhancer of

Statement

Reference

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is an enhancer of abnormal neuroanatomy | third instar larval stage | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is an enhancer of visible | adult stage | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is an enhancer of homeotic | adult stage | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is an enhancer of visible | adult stage | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

NOT Enhancer of

Statement

Reference

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is a non-enhancer of abnormal size | adult stage | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-enhancer of homeotic | adult stage | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is a non-enhancer of abnormal size | third instar larval stage | somatic clone phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-enhancer of abnormal size | adult stage | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-enhancer of visible | adult stage | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

Suppressor of

Statement

Reference

dan^ems3/dan[+] is a suppressor | partially of abnormal size | adult stage phenotype of CtBP^GSA396, Scer\GAL4^ey.PU

(Hoang et al., 2010)

dan^ems3/dan[+] is a suppressor | partially of visible | adult stage phenotype of CtBP^GSA396, Scer\GAL4^ey.PU

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a suppressor of abnormal size | adult stage | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

NOT Suppressor of

Statement

Reference

dan^ems3/dan^ems3 is a non-suppressor of homeotic | adult stage | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is a non-suppressor of abnormal size | adult stage | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is a non-suppressor of abnormal size | somatic clone | third instar larval stage phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-suppressor of lethal - all die before end of larval stage phenotype of CtBP^87De-10

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is a non-suppressor of lethal - all die before end of larval stage phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-suppressor of abnormal size | adult stage | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-suppressor of visible | adult stage | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

Other

Statement

Reference

dan^ems3, danr^ex35 has visible | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

dan^ems3, danr^ex35 has abnormal neuroanatomy | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

dan^ems3, danr^ex35 has homeotic | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3, danr^ex35 has abnormal cell number | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3, danr^ex35 has abnormal neuroanatomy | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3 has abnormal size | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3 has visible | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

dan^ems3, danr^ex35 has antenna | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3, danr^ex35 has eye | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3 has antenna | somatic clone - Minute background phenotype, enhanceable by danr^ex35/danr^ex35/CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3 has antenna | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

dan^ems3 has eye | somatic clone - Minute background phenotype, enhanceable by CtBP^87De-10/CtBP^87De-10

(Hoang et al., 2010)

NOT Enhanced by

Statement

Reference

dan^ems3 has antenna | somatic clone - Minute background phenotype, non-enhanceable by danr^ex35/danr^ex35

(Hoang et al., 2010)

Suppressed by

Statement

Reference

CtBP^87De-10, dan^ems3 has ommatidium | somatic clone - Minute background phenotype, suppressible | partially by danr^ex35/danr^ex35

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3 has eye | somatic clone - Minute background phenotype, suppressible | partially by danr^ex35/danr^ex35

(Hoang et al., 2010)

NOT suppressed by

Statement

Reference

dan^ems3 has antenna | somatic clone - Minute background phenotype, non-suppressible by danr^ex35/danr^ex35

(Hoang et al., 2010)

Enhancer of

Statement

Reference

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is an enhancer of antenna | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is an enhancer of antenna | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is an enhancer of eye | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is an enhancer of antenna | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is an enhancer of eye | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is an enhancer of eye disc | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

NOT Enhancer of

Statement

Reference

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is a non-enhancer of eye disc anterior to the morphogenetic furrow | third instar larval stage | somatic clone phenotype of CtBP^87De-10

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is a non-enhancer of adult head bristle | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is a non-enhancer of ommatidium | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is a non-enhancer of eye | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-enhancer of ommatidium | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-enhancer of eye | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-enhancer of adult head bristle | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-enhancer of antenna | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

Suppressor of

Statement

Reference

dan^ems3/dan[+] is a suppressor | partially of interommatidial bristle | increased number phenotype of CtBP^GSA396, Scer\GAL4^ey.PU

(Hoang et al., 2010)

dan^ems3/dan[+] is a suppressor | partially of eye phenotype of CtBP^GSA396, Scer\GAL4^ey.PU

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a suppressor of ommatidium | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a suppressor of eye | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

NOT Suppressor of

Statement

Reference

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is a non-suppressor of eye disc anterior to the morphogenetic furrow | somatic clone | third instar larval stage phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-suppressor of adult head bristle | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-suppressor of antenna | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is a non-suppressor of ommatidium | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

dan^ems3, dan^ems3, CtBP^87De-10, CtBP^87De-10 is a non-suppressor of eye | somatic clone - Minute background phenotype of danr^ex35

(Hoang et al., 2010)

danr^ex35, danr^ex35, dan^ems3, dan^ems3 is a non-suppressor of adult head bristle | somatic clone - Minute background phenotype of CtBP^87De-10

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-suppressor of ommatidium | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

dan^ems3/dan^ems3 is a non-suppressor of eye | somatic clone - Minute background phenotype of CtBP^87De-10, danr^ex35

(Hoang et al., 2010)

Other

Statement

Reference

CtBP^87De-10, dan^ems3, danr^ex35 has eye photoreceptor cell | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3, danr^ex35 has inner photoreceptor cell | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

dan^ems3, danr^ex35 has antenna | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3, danr^ex35 has outer photoreceptor cell | adult stage | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3 has eye | somatic clone - Minute background phenotype

(Hoang et al., 2010)

CtBP^87De-10, dan^ems3 has ommatidium | somatic clone - Minute background phenotype

(Hoang et al., 2010)

dan^ems3, danr^ex35 has eye | somatic clone - Minute background phenotype

(Hoang et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

danr^ex35 dan^ems3 double heterozygotes do not exhibit any visible eye phenotypes as single heterozygotes or control adults.

Mosaic animals with dan^ems3 danr^ex35 double homozygous clones (in Minute background) exhibit gaps in the ommatidial array when compared to controls. While pre-morphogenetic-furrow dan^ems3 danr^ex35 double homozygous clones do not exhibit any alterations in size in the third instar larval eye-antennal discs when compared to controls.

Mosaic animals with CtBP^87De-10 dan^ems3 danr^ex35 triple homozygous clones (in Minute background) exhibit defects in ommatidia with a higher frequency when compared to dan^ems3 danr^ex35 double homozygous clones (in Minute background).

Mosaic animals with CtBP^87De-10 dan^ems3 double homozygous clones exhibit significantly fewer ommatidia than single homozygous mosaic eyes and control clones.

(Hoang et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dan^emS3

(An et al., 2023)

dan^ems3

(Hoang et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (3)

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