FlyBase Allele Report: Dmel\comm[072]

General Information

Symbol

Dmel\comm⁰⁷²

Species

D. melanogaster

Name

FlyBase ID

FBal0144390

Feature type

allele

Associated gene

Dmel\comm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: ?69term.

(Keleman et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:15,728,000..15,728,000 [-]

Nucleotide change:

C15728000T

Amino acid change:

Q69term | comm-PA; Q69term | comm-PB

Reported amino acid change:

?69term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Keleman et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage 16

(Keleman et al., 2005)

Phenotype Manifest In

commissure | embryonic stage 16

(Keleman et al., 2005)

Detailed Description

Statement

Reference

Unlike in wild type, the poxn neurons never cross the midline in comm⁰⁷² homozygous stage 16 embryos. The ipsilateral ap neurons do not cross in comm⁰⁷² mutants.

(Keleman et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

comm⁰⁷² has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by robo1^CS

(Gilestro, 2008)

comm⁰⁷² has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by fra::robo1^SD

(Gilestro, 2008)

comm⁰⁷² has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by robo1^SD-CD8

(Gilestro, 2008)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

comm⁰⁷² has symmetrical commissure | embryonic stage phenotype, non-suppressible by robo1^CS

(Gilestro, 2008)

comm⁰⁷² has symmetrical commissure | embryonic stage phenotype, non-suppressible by fra::robo1^SD

(Gilestro, 2008)

comm⁰⁷² has symmetrical commissure | embryonic stage phenotype, non-suppressible by robo1^SD-CD8

(Gilestro, 2008)

Additional Comments

Genetic Interactions

Statement

Reference

robo^CS has no suppressive effect on the commissure loss seen in comm⁰⁷² mutant embryos.

fra::robo^SD has no suppressive effect on the commissure loss seen in comm⁰⁷² mutant embryos.

robo^SD-CD8 has no suppressive effect on the commissure loss seen in comm⁰⁷² mutant embryos.

(Gilestro, 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

comm⁰⁷² is rescued by comm^{KR.UAS.Tag:HA}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

Partially rescued by

comm⁰⁷² is partially rescued by comm^UAS.Tag:MYC/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^UAS.Tag:MYC/comm^sli.Tag:MYC/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^sim.Tag:MYC/comm^UAS.Tag:MYC/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^sli.Tag:MYC/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^sim.Tag:MYC/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^{Δ2-36.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^{Δ2-58.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^{Δ2-98.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^{Δ35-108.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^{Δ57-108.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^{Δ91-108.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

comm⁰⁷² is partially rescued by comm^{Δ132-160:CD8.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

Not rescued by

comm⁰⁷² is not rescued by comm^{Δ108-131:CD8.UAS.Tag:MYC}/Scer\GAL4^Poxn.14

(Keleman et al., 2005)

Comments

Expression of comm^{Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos. At least one midline crossing occurs correctly in 67% of the segments.

Expression of comm^{Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14, with expression of comm in the midline using comm^{sli.T:Hsap\MYC}, partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14, with expression of comm in the midline using comm^{sim.T:Hsap\MYC}, partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ2-36.Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ2-58.Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ2-98.Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ35-108.Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ57-108.Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ91-108.Scer\UAS.T:Hsap\MYC} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ108-131.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a} in the poxn neurons under the control of Scer\GAL4^Poxn.14 does not rescue the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{Δ132-160.Scer\UAS.T:Hsap\MYC,T:Mmus\Cd8a} in the poxn neurons under the control of Scer\GAL4^Poxn.14 partially rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

Expression of comm^{KR.Scer\UAS.T:Ivir\HA1} in the poxn neurons under the control of Scer\GAL4^Poxn.14 rescues the midline crossing defects seen in comm⁰⁷² stage 16 embryos.

(Keleman et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

comm⁰⁷²

(Gilestro, 2008)

comm^O72

(Keleman et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (3)

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