FlyBase Allele Report: Dmel\mGluR[UAS.cRa]

General Information

Symbol

Dmel\mGluR^UAS.cRa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Ramaekers

FlyBase ID

FBal0144863

Feature type

allele

Associated gene

Dmel\mGluR

Associated Insertion(s)

Carried in Construct

P{UAS-Glu-RA.R}

Key Links

Transgenic product class

cDNA

(Ramaekers et al., 2001)

wild_type

(Ramaekers et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Ramaekers et al., 2001)

wild_type

(Ramaekers et al., 2001)

Mutagen

in vitro construct

(Ramaekers et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-Glu-RA.R}

Cytology

Description

UAS regulatory sequences drive expression of a P{UAS-Glu-RA.R} cDNA.

(Ramaekers et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

mGluR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^BG380

(Bogdanik et al., 2004)

abnormal neuroanatomy, with Scer\GAL4^RapGAP1-OK6

(Bogdanik et al., 2004)

Phenotype Manifest In

bouton | increased number, with Scer\GAL4^BG380

(Bogdanik et al., 2004)

bouton | increased number, with Scer\GAL4^RapGAP1-OK6

(Bogdanik et al., 2004)

Detailed Description

Statement

Reference

Expression of mGluRA^Scer\UAS.cRa in neurons, under the control of either Scer\GAL4^BG380 or Scer\GAL4^OK6, results in an increase of bouton number in larval neuromuscular junctions.

(Bogdanik et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa

(Bogdanik et al., 2004)

Suppressor of

Statement

Reference

Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa

(Bogdanik et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa has bouton | increased number phenotype, suppressible by Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa

(Bogdanik et al., 2004)

Suppressor of

Statement

Reference

Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa is a suppressor of bouton | increased number phenotype of Scer\GAL4^RapGAP1-OK6, mGluR^UAS.cRa

(Bogdanik et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

A Gβ13F/+ background suppresses the increase in synaptic bouton number seen when mGluRA^Scer\UAS.cRa is expressed under the control of Scer\GAL4^OK6 in a wild-type background.

(Bogdanik et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

mGluR^UAS.cRa/Scer\GAL4^BG380 rescues mGluR^112b

(Bogdanik et al., 2004)

Fails to rescue

mGluR^UAS.cRa/Scer\GAL4^Mhc.PW fails to rescue mGluR^112b

(Bogdanik et al., 2004)

Comments