FlyBase Allele Report: Dmel\DptA[UAS.cTa]

General Information

Symbol

Dmel\DptA^UAS.cTa

Species

D. melanogaster

Name

FlyBase ID

FBal0145047

Feature type

allele

Associated gene

Dmel\DptA

Associated Insertion(s)

Carried in Construct

P{UAS-DptA.T}

Also Known As

UAS-Dpt

Key Links

Transgenic product class

wild_type

(Tzou et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Tzou et al., 2002)

Mutagen

in vitro construct

(Tzou et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-DptA.T}

Cytology

Description

Expression of DptA (350-bp EcoRI fragment) is under the control of UASt sequences.

(Tzou et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

DptA

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response, with Scer\GAL4^Act.PU

(Zhao et al., 2010)

abnormal oxidative stress response, with Scer\GAL4^da.PU

(Zhao et al., 2010)

viable, with Scer\GAL4^da.G32

(Tzou et al., 2002)

Phenotype Manifest In

adult posterior midgut epithelium, with Scer\GAL4^da.G32

(Ryu et al., 2008)

Detailed Description

Statement

Reference

Expression of DptA^Scer\UAS.cTa under the control of either Scer\GAL4^da.PU or Scer\GAL4^Act.PU significantly increases tolerance to high hyperoxia compared to controls - the flies are able to develop and eclose (with a rate of around 50% or 60%) in an environment with 90% O[[2]].

(Zhao et al., 2010)

Flies expressing Dpt^Scer\UAS.cTa under the control of Scer\GAL4^da.G32 show a high level of gut epithelial cell apoptosis (this cell death is not seen in control flies). The commensal bacterial population in the intestine is altered compared to wild type in these flies.

(Ryu et al., 2008)

Expression of Dpt^Scer\UAS.cTa under the control of Scer\GAL4^c564 increases the survival of flies that have been injected with both E.coli and the fungal peptide Destruxin A.

(Pal et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dpt^Scer\UAS.cTa

DptA^Scer\UAS.cTa

DptA^UAS.cTa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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