FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pinsunspecified
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General Information
Symbol
Dmel\pinsunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0146865
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The spindle is asymmetric in telophase pI cells (6/8) of rapsunspecified homozygous pupae; however, in this case the spindle posterior arm is preferentially extended relative to the anterior spindle arm.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference
    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    pinsunspecified is an enhancer of astral microtubule & neuroblast | ectopic phenotype of locoP283

    pinsunspecified is an enhancer of neuroblast phenotype of locoP283

    Suppressor of
    Statement
    Reference
    Other
    Statement
    Reference

    insc22, pinsunspecified has spindle pole centrosome & astral microtubule phenotype

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    In embryos derived from double germline clones of locoP283 and rapsunspecified, the majority of neuroblasts undergo symmetric divisions to generate two similar-sized daughter cells in stage 10 mutant embryos, in 60% of cases. The cleavage plane is placed near the middle of the two centrosomes and the spindle is positioned symmetrically with both centrosomes lying in close proximity to the cell cortex. Astral microtubules, which are normally associated only with the apical centrosome in wild-type neuroblasts, can emanate from both centrosomes in locoP283 and rapsunspecified double mutant neuroblasts.

    In rapsunspecified insc22 double mutant neuroblasts, both centrosomes are associated with astral microtubules, with a cap structure forming over each centrosome from metaphase onwards. This phenotype is not observed in single mutants for these genes. Expression of G-iα65AScer\UAS.cCa, under the regulation of Scer\GAL4mat.αTub67C.T:Hsim\VP16 in a rapsunspecified background results in equal size division occurring in 62% of neuroblasts.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    pinsunspecified
    rapsunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (4)