FB2026_02 , released June 18, 2026
Allele: Dmel\crqKG01679
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General Information
Symbol
Dmel\crqKG01679
Species
D. melanogaster
Name
FlyBase ID
FBal0147219
Feature type
allele
Associated gene
Dmel\crq
Associated Insertion(s)
P{SUPor-P}crqKG01679
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}crqKG01679
Cytology
Description

Insertion in the first untranslated exon.

(Dolezal et al., 2005)
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      crqKG01679/Df(2L)al mutant pupae exhibit defects in phagocytic clearance of ddaC neuron dendrite debris following pupal stage dendritic pruning. Similarly, unlike in wild type, crqKG01679/Df(2L)al mutant larval in which the dendrites that have been injured (severed with an infrared laser) exhibit defects in debris clearance.

      Unlike phagolysosomes in wild type epidermal cells that are characterized by heterogeneous contents such as vesicles, particles, and multilayers of membrane, phagosomes in crqKG01679/Df(2L)al epidermal cells appear more homogeneous in content. In contrast to the wild type, crqKG01679/Df(2L)al epidermal cells contain many large-sized phagosomes that appear to arise from phagosome fusion.

      (Han et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      crqKG01679/crqKG01679 is a suppressor of melanotic mass phenotype phenotype of Dp(3;3)Karel

      (Dolezal et al., 2005)

      crq[+]/crqKG01679 is a suppressor | partially of melanotic mass phenotype phenotype of Dp(3;3)Karel

      (Dolezal et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      crqKG01679 Dp(3;3)Karel double mutant third instar larvae show a decrease in the total number of circulating hemocytes compared to Dp(3;3)Karel single mutants, although the number is still significantly increased compared to wild-type, and the cells show increased clumping. Lamellocytes are not detected in the double mutant larvae and the number of crystal cells is normal. The disintegration of the fat body and the formation of melanotic tumours seen in Dp(3;3)Karel single mutant larvae is completely suppressed in the double mutant. crqKG01679/+ Dp(3;3)Karel/Dp(3;3)Karel larvae show significant suppression of the fat body disintegration seen in Dp(3;3)Karel single mutants and rarely have melanotic tumours.

      (Dolezal et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      crqKG01679
      Name Synonyms
      Secondary FlyBase IDs
        References (4)