FlyBase Allele Report: Dmel\Lsd-2[51]

General Information

Symbol

Dmel\Lsd-2⁵¹

Species

D. melanogaster

Name

FlyBase ID

FBal0147806

Feature type

allele

Associated gene

Dmel\Lsd-2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gronke, 2003, Gronke et al., 2003)

Progenitor genotype

Lsd-2^KG00149

(Gronke, 2003, Gronke et al., 2003)

Cytology

Description

Imprecise excision of the P{SUPor-P} from Lsd-2^KG00149 has created this allele, nucleotides -34 to +654 (relative to the putative translation start codon) have been deleted.

(Gronke et al., 2003)

Deletion of nucleotides -34 to +654 (relative to the putative Lsd-2 translation start codon). Generated by imprecise excision of the P{SUPor-P}Lsd-2^KG00149 insertion.

(Gronke, 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:15,075,285..15,075,974 [-]

Comment:

Deletion resulting from the imprecise excision of P{SUPor-P}Lsd-2^KG00149.

(Gronke et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

fat body

(Gronke et al., 2003)

Detailed Description

Statement

Reference

Immature adult Lsd-2⁵¹ flies have less storage fat (measured as triacylglycerol content) than control flies.

(Gronke et al., 2005)

Mutants are lean, containing significantly lower levels of triacylglycerols (34.5% of controls).

(Gronke et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Lsd-2⁵¹ has phenotype, suppressible by bmm¹

(Gronke et al., 2005)

Suppressor of

Statement

Reference

Lsd-2⁵¹ is a suppressor of phenotype of bmm¹

(Gronke et al., 2005)

Other

Statement

Reference

Lsd-1¹, Lsd-2⁵¹ has lipid droplet phenotype

(Beller et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Lsd-1¹ Lsd-2⁵¹ double mutant adults have strongly reduced body fat stores at hatching (in contrast to the normal levels seen in newly hatched single mutants). The double mutants recover to have levels of stored body fat which are similar to those seen in the lean Lsd-2⁵¹ single mutants within the first 6 days after eclosion. The fat body cells contain large lipid droplets. During aging, the fat content of the double mutants is adjusted to a level between the level seen in each single mutant. Under a starvation/re-feeding scheme, the double mutant flies show attenuated lipid metabolism and re-accumulation compared to controls flies.

(Beller et al., 2010)

bmm¹, Lsd-2⁵¹ double mutants have wild type fat storage levels (as measured by triacylglycerol content), indicating that loss of Lsd-2 compensates for lack of bmm and vice versa.

(Gronke et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

98125

y¹ Lsd-2⁵¹/FM7i

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Lsd-2⁵¹

(Beller et al., 2006, Gronke et al., 2005)

Lsd2⁵¹

(Skorupa et al., 2007)

plin2⁵¹

(May et al., 2019, Beller et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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