FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SREBP52
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General Information
Symbol
Dmel\SREBP52
Species
D. melanogaster
Name
FlyBase ID
FBal0147883
Feature type
allele
Associated gene
Dmel\SREBP
Associated Insertion(s)
PBac{GAL4D,EYFP}SREBP52
Carried in Construct
Also Known As
dSREBP52
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Horn et al., 2003)
Progenitor genotype
Associated Insertion(s)
PBac{GAL4D,EYFP}SREBP52
Cytology
Description

Insertion 3bp into exon 1.

(Kunte et al., 2006)

PBac{GAL4D,EYFP} insertion in an exon of HLH106. The insertion site is at position 16226 of accession number AE003515.2.

(Horn et al., 2003)
Allele components
Component
Use(s)
Inserted element
PBac{GAL4D,EYFP}
Encoded product / tool
GAL4(II-9)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  heart conduction disease
      modeled by eas2
      (Lim et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      HLH10652/HLH106189 first instar larvae contain significantly less total fatty acid than wild-type controls, but the relative abundance of various fatty acid species does not differ significantly from that of controls.

      (Kunte et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      SREBP52/HLH106[+] is a suppressor of adult heart phenotype of eas2

      (Lim et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased whole fly triglyceride levels seen in 1 week old eas2 females are suppressed if they are also carrying HLH10652/+.

      HLH10652/+ rescues the increased heartbeat rate and constricted heart phenotypes of eas2 flies.

      (Lim et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: an unrelated pupal lethal mutation on the same chromosome.

      (Kunte et al., 2006)
      Comments
      Comments

      Excision of the PBac{GAL4D,EYFP} element can revert the lethal phenotype.

      (Horn et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      HLH10652
      SREBP52
      (Diop et al., 2015)
      SREBPΔ52
      (Sieber and Spradling, 2015)
      dSREBP52
      (Lim et al., 2011, Kunte et al., 2006)
      line 52
      (Horn et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)