FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gbKG07905
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General Information
Symbol
Dmel\gbKG07905
Species
D. melanogaster
Name
FlyBase ID
FBal0148193
Feature type
allele
Associated gene
Dmel\gb
Associated Insertion(s)
P{SUPor-P}gbKG07905
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Augustin et al., 2007)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}gbKG07905
Cytology
Description

P{SUPor-P} insertion in the 5' UTR.

(Grosjean et al., 2008)

A P{SUPor-P} insertion in the first exon of the gb gene.

(Augustin et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      larval neuromuscular junction & postsynaptic membrane

      (Augustin et al., 2007)

      larval neuromuscular junction & postsynaptic membrane (with Df(3R)Exel6206)

      (Augustin et al., 2007)
      Detailed Description
      Statement
      Reference

      gbKG07905 flies show both increased susceptibility to S. aureus infection and decreased phagocytosis of S. aureus.

      (Gonzalez et al., 2013)

      gbKG07905 mutant flies show faster 'bang recovery' than controls: gbKG07905 mutant flies climb the vials approximately three times faster than either wildtype or precise excision controls. This may be because the upward trajectory of gbKG07905 flies is straighter than that of control flies. Accelerated 'bang recovery' is not dependent on age or sex.

      (Featherstone et al., 2008)

      Male flies carrying gbKG07905 show frequent homosexual interactions, including singing to other males, genital licking and attempted copulation.

      gbKG07905 males presented simultaneously with a wild-type passive (decapitated) male and a wild-type passive (decapitated) virgin female choose to court the male and female with equal intensity and probability (in contrast to wild-type males which always choose to court females). This phenotype is seen both when group and single-pair courtship assays are carried out.

      gbKG07905 males show much higher homosexual courtship under dim red light conditions (in which the flies are virtually blind) than control males under the same conditions.

      gbKG07905 males show abnormally high courtship levels to mated wild-type females.

      Significantly more gbKG07905 males are trapped in an olfactory trap assay using standard food as bait compared to controls.

      (Grosjean et al., 2008)

      The neuromuscular junctions of gbKG07905 and gbKG07905/Df(3R)Exel6206 larvae show a large increase in postsynaptic glutamate receptor number. Consistently, the mean amplitude of spontaneous excitatory junction currents (sEJCs) from the L3 muscle 6 NMJ is almost doubled in gbKG07905 and gbKG07905/Df(3R)Exel6206 larvae, but neither mutant shows an increase in sEJC frequency compared with wild-type controls.

      (Augustin et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      gbKG07905 has abnormal courtship behavior | male phenotype, suppressible | partially by mGluR112b

      (Grosjean et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The level of homosexual courtship of gbKG07905 males is reduced to wild-type levels when they are partnered with desat11573-1 males instead of with wild-type males.

      The high level of homosexual courtship behaviour that is seen in gbKG07905 males is partially suppressed if they are also mutant for mGluRA112b.

      (Grosjean et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference

      gbKG07905 males react normally to potential partners from other Drosophila species.

      (Grosjean et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the insertion completely rescues the mutant courtship phenotype.

      (Grosjean et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG6070KG07905
      gbKG07905
      (Titus et al., 2023, Featherstone et al., 2008, Grosjean et al., 2008, Augustin et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)