FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hpoGMR.PW
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General Information
Symbol
Dmel\hpoGMR.PW
Species
D. melanogaster
Name
glass multimer construct of Wu
FlyBase ID
FBal0151852
Feature type
allele
Associated gene
Dmel\hpo
Associated Insertion(s)
Carried in Construct
P{GMR-hpo.W}
Also Known As
GMR-Hpo
Key Links
Transgenic product class
cDNA
(Wu et al., 2003)
wild_type
(Wu et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wu et al., 2003)
wild_type
(Wu et al., 2003)
Mutagen
in vitro construct
(Wu et al., 2003)
Progenitor genotype
Carried in construct
P{GMR-hpo.W}
Cytology
Description

Expression of full length hpo cDNA (GH10354), is under the control of GMR.

(Wu et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
hpo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of hpoGMR.PW causes a reduction in eye size.

      (Poon et al., 2011)

      Expression of hpoGMR.PW results in adults with smaller eyes than normal.

      (Yu et al., 2010)

      hpoGMR.PW flies have rough eyes.

      (Wu et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      hpoGMR.PW has eye phenotype, suppressible by TaoKK108458/Scer\GAL4GMR.PF

      (Poon et al., 2011)

      hpoGMR.PW has eye phenotype, suppressible by BacA\p35GMR.PH

      (Wu et al., 2003)

      hpoGMR.PW has ommatidium phenotype, suppressible by BacA\p35GMR.PH

      (Wu et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of TaoKK108458 under the control of Scer\GAL4GMR.PF almost completely suppresses the reduced eye size seen when hpoGMR.PW is expressed.

      (Poon et al., 2011)

      The small eye phenotype caused by hpoGMR.PW is not affected if the eyes are also homozygous for kibradel.

      (Yu et al., 2010)

      Co-introduction of wtsGMR.PT and hpoGMR.PW results in 100% lethality at the early pupal stage. This lethality can be completely rescued by coexpression of ykiGMR.PH.

      (Huang et al., 2005)

      The rough eye phenotype due to hpoGMR.PW is largely suppressed by BacA\p35GMR.PH, but is enhanced by savGMR.PT. hpoGMR.PW is lethal in combination with wtsGMR.PT.

      (Wu et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference

      Co-introduction of wtsGMR.PT and hpoGMR.PW results in 100% lethality at the early pupal stage. This lethality can be completely rescued by coexpression of Hsap\YAP1Scer\UAS.cHa under the control of Scer\GAL4GMR.PF.

      (Huang et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hpoGMR.PW
      Name Synonyms
      glass multimer construct of Wu
      (Wu et al., 2003)
      Secondary FlyBase IDs
        References (6)